ArticleDevelopment (Cambridge, England)2014
Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Zebrafish sall1a and sall4 contribute to body elongation.Developmental biology · 2025Article
- Sall4 regulates downstream patterning genes during limb regeneration.Developmental biology · 2024Article
- Transcriptional Regulators with Broad Expression in the Zebrafish Spinal Cord.bioRxiv : the preprint server for biology · 2024Article
- Integrative Role of the SALL4 Gene: From Thalidomide Embryopathy to Genetic Defects of the Upper Limb, Internal Organs, Cerebral Midline, and Pituitary.Hormone research in paediatrics · 2024Review
- Positive feedback regulation ofeLife · 2022Article
- The functional diversity of the POUV-class proteins across vertebrates.Open biology · 2022Review
- Hif1α and Wnt are required for posterior gene expression during Xenopus tropicalis tail regeneration.Developmental biology · 2022Article
- Normal embryonic development and neonatal digit regeneration in mice overexpressing a stem cell factor, Sall4.PloS one · 2022Article
- Heterochromatin protein 1 beta regulates neural and neural crest development by repressing pluripotency-associated gene pou5f3.2/oct25 in Xenopus.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- The atypical RNA-binding protein Taf15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis.Development (Cambridge, England) · 2021Article
- The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis.Cell death & disease · 2021Article
- Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression.Cell reports · 2021Article
- New roles for Wnt and BMP signaling in neural anteroposterior patterning.EMBO reports · 2019Article
- Article
- Zebrafish Znfl1 proteins control the expression ofThe Journal of biological chemistry · 2017Article
- Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation.Developmental biology · 2017Article
- Review
- Tissue- and stage-specific Wnt target gene expression is controlled subsequent to β-catenin recruitment to cis-regulatory modules.Development (Cambridge, England) · 2016Article
- Early neural ectodermal genes are activated by Siamois and Twin during blastula stages.Genesis (New York, N.Y. : 2000) · 2015Article
- SALL4: engine of cell stemness.Current gene therapy · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Amphibian neural development occurs as a two-step process: (1) induction specifies a neural fate in undifferentiated ectoderm; and (2) transformation induces posterior spinal cord and hindbrain. Signaling through the Fgf, retinoic acid (RA) and Wnt/β-catenin pathways is necessary and sufficient to induce posterior fates in the neural plate, yet a mechanistic understanding of the process is lacking. Here, we screened for factors enriched in posterior neural tissue and identify spalt-like 4 (sall4), which is induced by Fgf. Knockdown of Sall4 results in loss of spinal cord marker expression and increased expression of pou5f3.2 (oct25), pou5f3.3 (oct60) and pou5f3.1 (oct91) (collectively, pou5f3 genes), the closest Xenopus homologs of mammalian stem cell factor Pou5f1 (Oct4). Overexpression of the pou5f3 genes results in the loss of spinal cord identity and knockdown of pou5f3 function restores spinal cord marker expression in Sall4 morphants. Finally, knockdown of Sall4 blocks the posteriorizing effects of Fgf and RA signaling in the neurectoderm. These results suggest that Sall4, activated by posteriorizing signals, represses the pou5f3 genes to provide a permissive environment allowing for additional Wnt/Fgf/RA signals to posteriorize the neural plate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.