ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Arginase and C-reactive protein as potential serum-based biomarker of head and neck squamous cell carcinoma patients of north east India.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer.Molecular oncology · 2026Review
- Serum Arginase-1 is a predictive biomarker for melanoma patients and a surrogate indicator of systemic myeloid cell fitness.Oncoimmunology · 2025Article
- Arginase-1 in Plasma-Derived Exosomes as Marker of Metastasis in Patients with Head and Neck Squamous Cell Carcinoma.Cancers · 2023Article
- The immunobiology of myeloid-derived suppressor cells in cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study.Medicine · 2016Article
- Tobacco carcinogen-metabolizing genes CYP1A1, GSTM1, and GSTT1 polymorphisms and their interaction with tobacco exposure influence the risk of head and neck cancer in Northeast Indian population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and neck squamous cell carcinoma (HNSCC) diagnosis involves histopathological investigations with intervention procedures. Widely accepted biochemical panels for HNSCC detection is not available yet. We tried to find out the effectiveness of the serum-based biochemical markers for their prognostic significance in HNSCC. We collected fresh blood samples of 80 HNSCC patients and 100 healthy subjects. Samples were analyzed for absolute levels of arginase (ARG), ornithine aminotransferase (OAT), catalase (CAT), lactate dehydrogenase (LDH), amylase (AMY) activity, and C-reactive protein (CRP). Receiver-operator characteristic curves and Fagan's nomograms were generated. Out of six parameters studied, four (OAT, CAT, LDH, and AMY) did not show biologically significant differences to be used as biomarkers. Significant elevation in serum ARG and CRP levels were observed in HNSCC. The individual estimation of ARG and CRP showed lower specificity, but their combination improved the specificity level to 95%. Our results suggest that serum ARG and CRP together can efficiently diagnose HNSCC.
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