ArticlePediatric cardiology2014
miR-10a and miR-10b target the 3'-untranslated region of TBX5 to repress its expression.
Article in Pediatric cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Case report: Novel TBX5-related pathogenic mechanism of Holt-Oram syndrome.Frontiers in genetics · 2023Article
- MicroRNA composition of plasma extracellular vesicles: a harbinger of late cardiotoxicity of doxorubicin.Molecular medicine (Cambridge, Mass.) · 2022Article
- Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis.Annals of the rheumatic diseases · 2022Article
- A narrative review of non-coding RNAs in atrial fibrillation: potential therapeutic targets and molecular mechanisms.Annals of translational medicine · 2021Review
- Differential Spatio-Temporal Regulation of T-Box Gene Expression by microRNAs during Cardiac Development.Journal of cardiovascular development and disease · 2021Article
- Identification of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA theory reveals functional lncRNAs in hypertrophic cardiomyopathy.Experimental and therapeutic medicine · 2020Article
- Ppp1r1b-lncRNA inhibits PRC2 at myogenic regulatory genes to promote cardiac and skeletal muscle development in mouse and human.RNA (New York, N.Y.) · 2020Article
- Identification and functional analysis of genetic variants in TBX5 gene promoter in patients with acute myocardial infarction.BMC cardiovascular disorders · 2019Article
- Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human.Frontiers in physiology · 2019Article
- Interplay between cardiac transcription factors and non-coding RNAs in predisposing to atrial fibrillation.Journal of molecular medicine (Berlin, Germany) · 2018Review
- MiR-1-3p that correlates with left ventricular function of HCM can serve as a potential target and differentiate HCM from DCM.Journal of translational medicine · 2018Article
- Identification of a novel non-sense mutation inJournal of cardiovascular and thoracic research · 2018Article
- Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.Circulation research · 2017Article
- TBX5: A Key Regulator of Heart Development.Current topics in developmental biology · 2017Review
- A TBX5 3'UTR variant increases the risk of congenital heart disease in the Han Chinese population.Cell discovery · 2017Article
- Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease.Heart failure reviews · 2016Review
- Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways.Cancer research · 2016Article
- Extracellular MicroRNA in liquid biopsy: applicability in cancer diagnosis and prevention.American journal of cancer research · 2016Review
- Circulating microRNAs as potential biomarkers for diagnosis of congenital heart defects.World journal of emergency medicine · 2016Review
- Role of microRNAs in Alcohol-Induced Multi-Organ Injury.Biomolecules · 2015Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a well-known transcription factor, TBX5 is involved in embryonic cardiac development. Although TBX5 functions in a dose-dependent manner, the posttranscriptional regulation of human TBX5 is poorly understood. Thus, this study aimed to identify microRNAs that modulate TBX5 expression. Luciferase assays were used to screen miRNAs predicted to modulate TBX5 expression. Using quantitative reverse transcriptase-polymerase chain reaction and Western blot analysis, the authors found that miR-10a and miR-10b significantly repressed TBX5 expression and decreased TBX5 protein levels by targeting the TBX5 3'-untranslated region. In addition, miR-10a and miR-10b expression levels were respectively 2.77 and 3.51 times higher in the heart tissues of congenital heart disease patients than in healthy control subjects, suggesting that they are potential diagnostic biomarkers. In conclusion, the study results indicate that miR-10a and miR-10b inhibit TBX5 expression at the level of translation. Higher levels of miR-10a and miR-10b expression are associated with a higher risk of congenital heart defects.
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Registered trials
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