ArticleClinics (Sao Paulo, Brazil)2014
Fibrinogen and thrombin concentrations are critical for fibrin glue adherence in rat high-risk colon anastomoses.
Article in Clinics (Sao Paulo, Brazil), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Engineering Regenerative Fibrin Scaffold from Balanced Protein-Concentrate Plasma: Structural and Biochemical Characterization.Pharmaceutics · 2025Article
- Experimental models of high-risk bowel anastomosis in rats: A systematic review.World journal of experimental medicine · 2024Article
- A Novel Fibrin Matrix Derived from Platelet-Rich Plasma: Protocol and Characterization.International journal of molecular sciences · 2024Article
- Medical Adhesives and Their Role in Laparoscopic Surgery-A Review of Literature.Materials (Basel, Switzerland) · 2022Review
- Development of an In Situ Printing System With Human Platelet Lysate-Based Bio-Adhesive to Treat Corneal Perforations.Translational vision science & technology · 2022Article
- A Fibrin Coating Method of Polypropylene Meshes Enables the Adhesion of Menstrual Blood-Derived Mesenchymal Stromal Cells: A New Delivery Strategy for Stem Cell-Based Therapies.International journal of molecular sciences · 2021Article
- The effect of fibrin formulation on cell migration in an in vitro tendon repair model.Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2021Article
- In vivo evaluation of Mg-6Zn and titanium alloys on collagen metabolism in the healing of intestinal anastomosis.Scientific reports · 2017Article
- Effect of Fibrin Formulation on Initial Strength of Tendon Repair and Migration of Bone Marrow Stromal Cells in Vitro.The Journal of bone and joint surgery. American volume · 2015Article
- Our 20-year experience with experimental colonic anastomotic healing.Journal of medicine and lifeReview
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFibrin glues have not been consistently successful in preventing the dehiscence of high-risk colonic anastomoses. Fibrinogen and thrombin concentrations in glues determine their ability to function as sealants, healers, and/or adhesives. The objective of the current study was to compare the effects of different concentrations of fibrinogen and thrombin on bursting pressure, leaks, dehiscence, and morphology of high-risk ischemic colonic anastomoses using fibrin glue in rats.
methodsColonic anastomoses in adult female Sprague-Dawley rats (weight, 250-350 g) treated with fibrin glue containing different concentrations of fibrinogen and thrombin were evaluated at post-operative day 5. The interventions were low-risk (normal) or high-risk (ischemic) end-to-end colonic anastomoses using polypropylene sutures and topical application of fibrinogen at high (120 mg/mL) or low (40 mg/mL) concentrations and thrombin at high (1000 IU/mL) or low (500 IU/mL) concentrations.
resultsIschemia alone, anastomosis alone, or both together reduced the bursting pressure. Glues containing a low fibrinogen concentration improved this parameter in all cases. High thrombin in combination with low fibrinogen also improved adherence exclusively in low-risk anastomoses. No differences were detected with respect to macroscopic parameters, histopathology, or hydroxyproline content at 5 days post-anastomosis.
conclusionsFibrin glue with a low fibrinogen content normalizes the bursting pressure of high-risk ischemic left-colon anastomoses in rats at day 5 after surgery.
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