Evidence map›Paper›PMID 24714816›Full record

Trial reportBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2014

Salivary testosterone and immunoglobulin A were increased by resistance training in adults with Down syndrome.

G Fornieles, M A Rosety, S Elosegui, J M Rosety, J R Alvero-Cruz, N Garcia, M Rosety, T Rodriguez-Pareja, R Toro, M Rosety-Rodriguez and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Effectiveness of Resistance Training in People With Down Syndrome: Systematic Review and Meta-Analysis.Journal of applied research in intellectual disabilities : JARID · 2026
    Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

G FornielesSchool of Medicine, University of Cadiz, Cadiz, Spain.
M A RosetySchool of Sports Sciences, University of Cadiz, Cadiz, Spain.
S EloseguiSchool of Medicine, University of Cadiz, Cadiz, Spain.
J M RosetyDivision of Urology, University Hospital Puerta del Mar Cadiz, Cadiz, Spain.
J R Alvero-CruzSchool of Sports Medicine, University of Cadiz, Cadiz, Spain.
N GarciaSchool of Medicine, University of Cadiz, Cadiz, Spain.
M RosetySchool of Sports Medicine, University of Malaga, Malaga, Spain.
T Rodriguez-ParejaDivision of Gynecology, University Hospital Jerez, Cadiz, Spain.
R ToroSchool of Medicine, University of Cadiz, Cadiz, Spain.
M Rosety-RodriguezSchool of Medicine, University of Cadiz, Cadiz, Spain.
F J OrdonezSchool of Sports Medicine, University of Malaga, Malaga, Spain.
I RosetySchool of Medicine, University of Cadiz, Cadiz, Spain.
Universidad de Cádiz · ESUniversidad de Málaga · ESHospital Jerez Puerta del Sur · ESHospital Universitario Puerta del Mar · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to assess the influence of resistance training on salivary immunoglobulin A (IgA) levels and hormone profile in sedentary adults with Down syndrome (DS). A total of 40 male adults with DS were recruited for the trial through different community support groups for people with intellectual disabilities. All participants had medical approval for participation in physical activity. Twenty-four adults were randomly assigned to perform resistance training in a circuit with six stations, 3 days per week for 12 weeks. Training intensity was based on functioning in the eight-repetition maximum (8RM) test for each exercise. The control group included 16 age-, gender-, and BMI-matched adults with DS. Salivary IgA, testosterone, and cortisol levels were measured by ELISA. Work task performance was assessed using the repetitive weighted-box-stacking test. Resistance training significantly increased salivary IgA concentration (P=0.0120; d=0.94) and testosterone levels (P=0.0088; d=1.57) in the exercising group. Furthermore, it also improved work task performance. No changes were seen in the controls who had not exercised. In conclusion, a short-term resistance training protocol improved mucosal immunity response as well as salivary testosterone levels in sedentary adults with DS.

Indexed as

Circuit-Based ExerciseResistance TrainingAdolescentAdultBody Mass IndexDown SyndromeEnzyme-Linked Immunosorbent AssayHumansHydrocortisoneImmunoglobulin A, SecretoryMaleSalivaSedentary BehaviorStanford-Binet TestTask Performance and AnalysisTestosteroneHydrocortisoneImmunoglobulin A, SecretoryTestosterone

Identifiers

PMID24714816
PMCPMC4075300
OpenAlexW2099992599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.