ArticleArchives of dermatological research1989
Abnormal organization of keratin intermediate filaments in cultured keratinocytes of epidermolysis bullosa simplex.
Article in Archives of dermatological research, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 74 citations in OpenAlex.
- Shifts in keratin isoform expression activate motility signals during wound healing.Developmental cell · 2024Article
- Keratin isoform shifts modulate motility signals during wound healing.bioRxiv : the preprint server for biology · 2024Article
- Allele-specific CRISPR-Cas9 editing of dominant epidermolysis bullosa simplex in human epidermal stem cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Scaling up single-cell mechanics to multicellular tissues - the role of the intermediate filament-desmosome network.Journal of cell science · 2020Review
- Traceless Targeting and Isolation of Gene-Edited Immortalized Keratinocytes from Epidermolysis Bullosa Simplex Patients.Molecular therapy. Methods & clinical development · 2017Article
- Discovery of keratin function and role in genetic diseases: the year that 1991 was.Molecular biology of the cell · 2016Review
- Distinct Impact of Two Keratin Mutations Causing Epidermolysis Bullosa Simplex on Keratinocyte Adhesion and Stiffness.The Journal of investigative dermatology · 2015Article
- A Drosophila Model of Epidermolysis Bullosa Simplex.The Journal of investigative dermatology · 2015Article
- Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath.The Journal of investigative dermatology · 2012Review
- The mechanical behavior of mutant K14-R125P keratin bundles and networks in NEB-1 keratinocytes.PloS one · 2012Article
- Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility.The Journal of clinical investigation · 2009Review
- Defining the properties of the nonhelical tail domain in type II keratin 5: insight from a bullous disease-causing mutation.Molecular biology of the cell · 2005Article
- Epidermolysis bullosa simplex-type mutations alter the dynamics of the keratin cytoskeleton and reveal a contribution of actin to the transport of keratin subunits.Molecular biology of the cell · 2004Article
- Keith R. Porter Lecture, 1996. Of mice and men: genetic disorders of the cytoskeleton.Molecular biology of the cell · 1997Review
- Defective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophy.The Journal of clinical investigation · 1996Article
- Intermediate filaments and disease: mutations that cripple cell strength.The Journal of cell biology · 1994Review
- Epidermolysis bullosa: hereditary skin fragility diseases as paradigms in cell biology.Archives of dermatological research · 1994Review
- Epidermolysis bullosa herpetiformis (Dowling-Meara type) exhibits ultrastructural derangement of tonofilaments and desmosomes.Archives of dermatological research · 1994Article
- The genetic basis of Weber-Cockayne epidermolysis bullosa simplex.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Disease severity correlates with position of keratin point mutations in patients with epidermolysis bullosa simplex.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Distinctive abnormality in the organization of keratin intermediate filaments (KIFs) was found for the first time in cultured epidermal keratinocytes from two patients with hereditary epidermolysis bullosa simplex (EBS), which showed cleavages above the basement membrane zone due to the fragility of basal cells. KIFs in EBS keratinocytes revealed an irregular radial arrangement composed of sparse but thick KIF bundles. Furthermore, these KIF bundles in many cells changed into numerous ball-like keratin aggregates and disappeared beyond these keratin aggregates in the peripheral cytoplasm. Electron microscopy of cultured EBS keratinocytes showed that many ball-like structures consisting of fine filaments or granules or homogeneous substances were scattered in the peripheral regions of the cell attaching to the dish, and intermediate filaments appeared to be emanating from or surrounding the structures. These ball-like keratin aggregates have never been observed in normal human keratinocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.