ArticlePloS one2014
Disturbed small-world networks and neurocognitive function in frontal lobe low-grade glioma patients.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Can cognitive function tests discriminate between patients with glioma and healthy controls prior to treatment? A systematic review.PloS one · 2025Pooled it
- Graph Theoretical Analysis of Brain Network Characteristics in Brain Tumor Patients: A Systematic Review.Neuropsychology review · 2022Pooled it
- Neurocognitive outcomes following glioma diagnosis and treatment: A systematic review.Brain & spine · 2026Review
- Review
- Alterations of gray matter volume and structural covariance network in unilateral frontal lobe low-grade gliomas.BMC medical imaging · 2025Article
- Pseudo-Resting-State Functional MRI Derived from Dynamic Susceptibility Contrast Perfusion MRI Can Predict Cognitive Impairment in Glioma.AJNR. American journal of neuroradiology · 2024Article
- Brain network topology and its cognitive impact in adult glioma survivors.Scientific reports · 2024Article
- Altered whole-brain functional network in patients with frontal low-grade gliomas: a resting-state functional MRI study.Neuroradiology · 2024Article
- Connectome-Based Neurosurgery in Primary Intra-Axial Neoplasms: Beyond the Traditional Modular Conception of Brain Architecture for the Preservation of Major Neurological Domains and Higher-Order Cognitive Functions.Life (Basel, Switzerland) · 2024Review
- Strength of spatial correlation between gray matter connectivity and patterns of proto-oncogene and neural network construction gene expression is associated with diffuse glioma survival.Frontiers in neurology · 2024Article
- Strength of spatial correlation between structural brain network connectivity and brain-wide patterns of proto-oncogene and neural network construction gene expression is associated with diffuse glioma survival.medRxiv : the preprint server for health sciences · 2023Article
- Brain network analysis reveals convergent and divergent aberrations between mild stroke patients with cortical and subcortical infarcts during cognitive task performing.Frontiers in aging neuroscience · 2023Article
- Predicting overall survival in diffuse glioma from the presurgical connectome.Scientific reports · 2022Article
- Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma.Neuro-oncology · 2022Article
- Tumor Connectomics: Mapping the Intra-Tumoral Complex Interaction Network Using Machine Learning.Cancers · 2022Article
- The small world coefficient 4.8 ± 1 optimizes information processing in 2D neuronal networks.NPJ systems biology and applications · 2022Article
- Neuroplasticity of Glioma Patients: Brain Structure and Topological Network.Frontiers in neurology · 2022Review
- White matter structural and network topological changes in moyamoya disease with limb paresthesia: A study based on diffusion kurtosis imaging.Frontiers in neuroscience · 2022Article
- Alternations and Applications of the Structural and Functional Connectome in Gliomas: A Mini-Review.Frontiers in neuroscience · 2022Review
- BOLD Coupling between Lesioned and Healthy Brain Is Associated with Glioma Patients' Recovery.Cancers · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain tumor patients often associated with losses of the small-world configuration and neurocognitive functions before operations. However, few studies were performed on the impairments of frontal lobe low-grade gliomas (LGG) after tumor resection using small-world network features. METHODOLOGY/PRINCIPAL
findingsTo detect differences in the whole brain topology among LGG patients before and after operation, a combined study of neurocognitive assessment and graph theoretical network analysis of fMRI data was performed. We collected resting-state fMRI data of 12 carefully selected frontal lobe LGG patients before and after operation. We calculated the topological properties of brain functional networks in the 12 LGG, and compared with 12 healthy controls (HCs). We also applied Montreal Cognitive Assessment (MoCA) in a subset of patients (n = 12, including before and after operation groups) and HCs (n = 12). The resulting functional connectivity matrices were constructed for all 12 patients, and binary network analysis was performed. In the range of 0.05 ≤ Kcos t ≤ 0.35, the functional networks in preoperative LGG and postoperative one both fitted the definition of small-worldness. We proposed Knet = 0.20 as small-world network interval, and the results showed that the topological properties were found to be disrupted in the two LGG groups, meanwhile the global efficiency increased and the local efficiency decreased. Lnet in the two LGG groups both were longer than HCs. Cnet in the LGG groups were smaller than HCs. Compared with the Hcs, MoCA in the two LGG groups were lower than HCs with significant difference, and the disturbed networks in the LGG were negatively related to worse MoCA scores.
conclusionsDisturbed small-worldness preperty in the two LGG groups was found and widely spread in the strength and spatial organization of brain networks, and the alterated small-world network may be responsible for cognitive dysfunction in frontal lobe LGG patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.