SynthesisPloS one2014
Serum uric acid levels in patients with Alzheimer's disease: a meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Serum uric acid levels in patients with amyotrophic lateral sclerosis: a meta-analysis.Scientific reports · 2018Pooled it
- Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies.BMJ (Clinical research ed.) · 2017Pooled it
- Investigating the nexus of metabolic syndrome, serum uric acid, and dementia risk: a prospective cohort study.BMC medicine · 2024Article
- The Influence of Serum Uric Acid on the Brain and Cognitive Dysfunction.Frontiers in psychiatry · 2022Review
- Hyperuricemia, Gout, and the Brain-an Update.Current rheumatology reports · 2021Review
- The Influence of Serum Uric Acid Level on Alzheimer's Disease: A Narrative Review.BioMed research international · 2021Review
- The relationship between serum uric acid and cognitive function in patients with chronic heart failure.BMC cardiovascular disorders · 2020Article
- Uric Acid and Hypertension: An Update With Recommendations.American journal of hypertension · 2020Review
- Associations of serum uric acid with incident dementia and cognitive decline in the ARIC-NCS cohort.Journal of the neurological sciences · 2020Article
- Association of sleep quality and sleep duration with serum uric acid levels in adults.PloS one · 2020Article
- Cause-Specific Mortality in Gout: Novel Findings of Elevated Risk of Non-Cardiovascular-Related Deaths.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Comparative effectiveness of allopurinol versus febuxostat for preventing incident dementia in older adults: a propensity-matched analysis.Arthritis research & therapy · 2018Article
- Uric Acid and Cognitive Function in Older Individuals.Nutrients · 2018Review
- Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer's Disease.Disease markers · 2018Article
- Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice.Journal of Alzheimer's disease : JAD · 2018Article
- Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017Article
- Assessment of serum uric acid as risk factor for tauopathies.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Recent advances in understanding and managing gout.F1000Research · 2017Review
- Uric Acid and the Risk of Alzheimer's Disease: Is There an Association?American journal of Alzheimer's disease and other dementias · 2016Article
- Serum Uric Acid and Its Association with Longitudinal Cognitive Change Among Urban Adults.Journal of Alzheimer's disease : JAD · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum uric acid (UA) could exert neuro-protective effects against Alzheimer's disease (AD) via its antioxidant capacities. Many studies investigated serum UA levels in AD patients, but to date, results from these observational studies are conflicting.
methodsWe conducted a meta-analysis to compare serum UA levels between AD patients and healthy controls by the random-effects model. Studies were identified by searching PubMed, ISI Web of Science, EMBASE, and the Cochrane library databases from 1966 through July 2013 using the Medical Subject Headings and keywords without restriction in languages. Only case-control studies were included if they had data on serum UA levels in AD patients and healthy controls. Begg's funnel plot and Egger's regression test were applied to assess the potential publication bias. Sensitivity analyses and meta-regression were conducted to explore possible explanations for heterogeneity.
resultsA total of 11 studies met the inclusion criteria including 2708 participants were abstracted. Serum UA levels were not significantly different in AD patients compared to healthy controls (standardized mean difference (SMD) = -0.50; 95% confidence interval (CI): -1.23 to 0.22). Little evidence of publication bias was observed. Sensitivity analyses showed that the combined SMD was consistent every time omitting any one study, except only one study which greatly influenced the overall results. Meta-regression showed that year of publication, race, sample size, and mean age were not significant sources of heterogeneity.
conclusionOur meta-analysis of case-control studies suggests that serum UA levels do not differ significantly in AD patients, but there may be a trend toward decreased UA in AD after an appropriate interpretation. More well-designed investigations are needed to demonstrate the potential change of serum UA levels in AD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.