ArticleeLife2014
Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 75 citations in OpenAlex.
- Article
- Characterization of EOP-1 reveals cell autonomous oscillations preceding somatic cell fusion in Neurospora crassa.PLoS genetics · 2026Article
- Role of cardiolipin in skeletal muscle function and its therapeutic implications.Cell communication and signaling : CCS · 2025Review
- Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.Nature communications · 2024Article
- Microwave-assisted preparation of yeast cells for ultrastructural analysis by electron microscopy.Microbial cell (Graz, Austria) · 2024Article
- Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology.Antioxidants & redox signaling · 2023Review
- Parallel evolution of two AIM24 protein subfamilies and their conserved functions in ER stress tolerance in land plants.Plant communications · 2023Article
- Barth Syndrome Cardiomyopathy: An Update.Genes · 2022Review
- Pathways shaping the mitochondrial inner membrane.Open biology · 2021Review
- Review
- Article
- Cardiolipin, the Mitochondrial Signature Lipid: Implication in Cancer.International journal of molecular sciences · 2020Review
- Altered Outer Hair Cell Mitochondrial and Subsurface Cisternae Connectomics Are Candidate Mechanisms for Hearing Loss in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes.Life science alliance · 2020Article
- Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Phospholipid ebb and flow makes mitochondria go.The Journal of cell biology · 2020Review
- MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation.The EMBO journal · 2020Article
- Absolute yeast mitochondrial proteome quantification reveals trade-off between biosynthesis and energy generation during diauxic shift.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- CmAim24 Is Essential for Mitochondrial Morphology, Conidiogenesis, and Mycoparasitism inApplied and environmental microbiology · 2020Article
- Metabolic Alterations in Inherited Cardiomyopathies.Journal of clinical medicine · 2019Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structure and function of mitochondria are intimately linked. In a search for components that participate in building the elaborate architecture of this complex organelle we have identified Aim24, an inner membrane protein. Aim24 interacts with the MICOS complex that is required for the formation of crista junctions and contact sites between inner and outer membranes. Aim24 is necessary for the integrity of the MICOS complex, for normal respiratory growth and mitochondrial ultrastructure. Modification of MICOS subunits Mic12 or Mic26 by His-tags in the absence of Aim24 leads to complete loss of cristae and respiratory complexes. In addition, the level of tafazzin, a cardiolipin transacylase, is drastically reduced and the composition of cardiolipin is modified like in mutants lacking tafazzin. In conclusion, Aim24 by interacting with the MICOS complex plays a key role in mitochondrial architecture, composition and function. DOI: http://dx.doi.org/10.7554/eLife.01684.001.
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Registered trials
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