Evidence map›Paper›PMID 24714346›Full record

ReviewLeukemia2014

MicroRNA theragnostics for the clinical management of multiple myeloma.

N Ahmad, S Haider, S Jagannathan, E Anaissie, J J Driscoll

Open access · hybridAbstract readReview
PubMed Publisher
In one paragraph

Review in Leukemia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. miRNAs Related to Immune Checkpoint Inhibitor Response: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Targeting microRNA in hematologic malignancies.Current opinion in oncology · 2020
    Review
  14. Article
  15. Article
  16. Review
  17. Autophagy · 2020
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

N AhmadDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
S HaiderDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
S Jagannathan1] Division of Hematology and Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, USA [2] The Vontz Center for Molecular Studies, Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
E Anaissie1] Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA [2] Division of Hematology and Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
J J Driscoll1] Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA [2] Division of Hematology and Oncology, University of Cincinnati College of Medicine, Cincinnati, OH, USA [3] The Vontz Center for Molecular Studies, Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA [4] Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
University of Cincinnati Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theragnostics represent cutting-edge, multi-disciplinary strategies that combine diagnostics with therapeutics in order to generate personalized therapies that improve patient outcome. In oncology, the approach is aimed at more accurate diagnosis of cancer, optimization of patient selection to identify those most likely to benefit from a specific therapy and to generate effective therapeutics that enhance patient survival. MicroRNAs (miRNAs) are master regulators of the human genome that orchestrate myriad cellular pathways to control growth during physiologic and pathologic conditions. Compelling evidence shows that miRNA deregulation promotes events linked to tumor initiation, metastasis and drug resistance as seen in multiple myeloma (MM), an invariably fatal hematologic malignancy. miRNAs are readily detected in body fluids, for example, serum, plasma, urine, as well as circulating tumor cells to demonstrate their potential as readily accessible, non-invasive diagnostic and prognostic biomarkers and potential therapeutics. Specific miRNAs are aberrantly expressed early in myelomagenesis and may more readily detect high-risk disease than current methods. Although only recently discovered miRNAs have rapidly advanced from preclinical studies to evaluation in human clinical trials. The development of miRNA theragnostics should provide widely applicable tools for the targeted delivery of personalized medicines to improve the outcome of patients with MM.

Indexed as

Gene Expression Regulation, NeoplasticHumansMicroRNAsMultiple MyelomaNeoplastic Cells, CirculatingPrecision MedicinePrognosisTranscriptomeMicroRNAs

Identifiers

PMID24714346
OpenAlexW2000903359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.