ArticleAnnals of gastroenterology2013
Clinical characteristics in patients with non-cardiac chest pain could favor gastroesophageal reflux disease diagnosis.
Article in Annals of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Comparing Efficacy and Safety of Empirical vs. Guided Therapy for Non-cardiac Chest Pain: A Pragmatic Randomized Trial.Frontiers in medicine · 2021Article
- The role of ambulatory 24-hour esophageal manometry in clinical practice.Neurogastroenterology and motility · 2020Review
- Is Noncardiac Chest Pain Truly Noncardiac?Clinical Medicine Insights. Cardiology · 2020Review
- History of gastroesophageal reflux disease in patients with suspected coronary artery disease.Heart and vessels · 2019Observational
- The high frequency of esophageal disorders in Iranian patients with non-cardiac chest pain.Gastroenterology and hepatology from bed to bench · 2018Article
- Determinants of the Association between Non-Cardiac Chest Pain and Reflux.The American journal of gastroenterology · 2017Article
- Health-related quality of life in gastroesophageal reflux patients with noncardiac chest pain: Emphasis on the role of psychological distress.World journal of gastroenterology · 2017Observational
- Screening and Identifying Erosive Esophagitis in Children with Non-cardiac Chest Pain.Journal of Korean medical science · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with non-cardiac chest pain (NCCP), gastroesophageal reflux disease (GERD) is thought to be the commonest cause. Ambulatory pH monitoring and/or endoscopy are usually performed in order to confirm GERD diagnosis. At present, clinical diagnosis of reflux in patients with NCCP is uncertain.The aim of the study was to determine clinical characteristics that could identify GERD in patients with NCCP.
methodsA total of 52 (age 52.8±1.8 yrs, 29 women) patients with NCCP underwent combined impedance-pH monitoring and gastroscopy. GERD diagnosis was based on the presence of esophagitis and/or a positive impedance-pH study (symptom index >50% and/or esophageal acid exposure time >4.0%). Patients were then divided into 2 groups: GERD- and non-GERD-related NCCP. Demographic and clinical parameters were compared between these two groups.
resultsGERD-related NCCP was found in 30 (58%) patients. Demographic characteristics were similar in both groups. Chest pain showed no difference in severity, radiation, relation to exercise and relation to sleep between the two groups. In the GERD-related NCCP group, chest pain was more prevalent during the postprandial period (P<0.05) and was relieved by spontaneous use of antireflux drugs (P<0.05). The presence of typical reflux symptoms favored a GERD diagnosis (P<0.05).
conclusionsA proportion of patients with NCCP showed clinical characteristics suggesting a GERD diagnosis. Typical reflux symptoms, postprandial chest pain and use of anti-reflux drugs for pain relief were the best predictors for GERD-related NCCP.
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Identifiers
24714293PMC3959479W2109281338What OpenQuestion holds
Registered trials
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