Evidence map›Paper›PMID 24714220›Full record

ReviewCell adhesion & migration2014

CCM1 and the second life of proteins in adhesion complexes.

Maaike C W van den Berg, Boudewijn M T Burgering

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell adhesion & migration, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Maaike C W van den BergCenter for Molecular Medicine; Dept. Molecular Cancer Research; University Medical Center Utrecht; The Netherlands.
Boudewijn M T BurgeringCenter for Molecular Medicine; Dept. Molecular Cancer Research; University Medical Center Utrecht; The Netherlands.
Center for Molecular Medicine and Immunology · USUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well recognized that a number of proteins present within adhesion complexes perform discrete signaling functions outside these adhesion complexes, including transcriptional control. In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus where it regulates the TCF transcription factor. Here we discuss nuclear functions of adhesion complex proteins with a special focus on the CCM-1/KRIT-1 protein, which may turn out to be yet another adhesion complex protein with a second life.

Indexed as

Transcription, Geneticbeta CateninCadherinsCell AdhesionHumansKRIT1 ProteinMicrotubule-Associated ProteinsMonomeric GTP-Binding ProteinsMultiprotein ComplexesProto-Oncogene Proteinsrac GTP-Binding ProteinsSignal Transductionbeta CateninCadherinsKRIT1 ProteinKRIT1 protein, humanMicrotubule-Associated ProteinsMonomeric GTP-Binding ProteinsMultiprotein ComplexesProto-Oncogene Proteinsrac GTP-Binding Proteinsadhesion signalingCCM1/Krit-1nuclear translocationRac Rhosmall GTPasestranscription

Identifiers

PMID24714220
PMCPMC4049860
OpenAlexW2034636047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.