Trial reportSocial cognitive and affective neuroscience2016
Mindfulness-based training attenuates insula response to an aversive interoceptive challenge.
Trial report in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Emotion Regulation and Coping in Active Military Personnel: A Systematic Review.Stress and health : journal of the International Society for the Investigation of Stress · 2025Pooled it
- Do mindfulness-based interventions change brain function in people with substance dependence? A systematic review of the fMRI evidence.BMC psychiatry · 2023Pooled it
- Neural mechanisms of mindfulness-based stress reduction in asthma.Scientific reports · 2026Trial
- Mindfulness meditation training in an occupational setting: Effects of a 12-weeks mindfulness-based intervention on wellbeing.Work (Reading, Mass.) · 2021Trial
- Mindfulness meditation regulates anterior insula activity during empathy for social pain.Human brain mapping · 2017Trial
- Preliminary Findings Supporting Insula Metabolic Activity as a Predictor of Outcome to Psychotherapy and Medication Treatments for Depression.The Journal of neuropsychiatry and clinical neurosciences · 2015Trial
- The Role of Heart Rate Variability in Mindfulness-Based Pain Relief.The journal of painTrial
- Selective interoception impairments and treatment effects in borderline personality disorder.Translational psychiatry · 2026Article
- Through Massage to the Brain-Neuronal and Neuroplastic Mechanisms of Massage Based on Various Neuroimaging Techniques (EEG, fMRI, and fNIRS).Journal of clinical medicine · 2026Review
- Mindful Attention Awareness and Residual Mood and Anxiety Symptoms in Remitted Patients With Bipolar I Disorder.Alpha psychiatry · 2025Article
- Identification of Brain Activation Areas in Response to Active Tactile Stimulation by Gripping a Stress Ball.Brain sciences · 2025Article
- Investigating the effect of mindfulness training for stress management in military training: the relationship between the autonomic nervous system and emotional regulation.BMC psychology · 2025Article
- The efficacy of meditation on insula dysfunction in patients with chronic schizophrenia.Frontiers in psychiatry · 2025Article
- Interoception: Synthesizing Insights and Charting New Frontiers.Current topics in behavioral neurosciences · 2025Review
- Mindfulness, cognition, and long-term meditators: Toward a science of advanced meditation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Trauma, early life stress, and mindfulness in adulthood.BMC psychology · 2024Review
- Physical Exercise to Redynamize Interoception in Substance use Disorders.Current neuropharmacology · 2024Article
- Meditation and interoception: a conceptual framework for the narrative and experiential self.Frontiers in psychology · 2024Review
- Article
- Promoting salutogenic pathways to health through complementary and integrative health approaches.Frontiers in psychology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Neuroimaging studies of mindfulness training (MT) modulate anterior cingulate cortex (ACC) and insula among other brain regions, which are important for attentional control, emotional regulation and interoception. Inspiratory breathing load (IBL) is an experimental approach to examine how an individual responds to an aversive stimulus. Military personnel are at increased risk for cognitive, emotional and physiological compromise as a consequence of prolonged exposure to stressful environments and, therefore, may benefit from MT. This study investigated whether MT modulates neural processing of interoceptive distress in infantry marines scheduled to undergo pre-deployment training and deployment to Afghanistan. Marines were divided into two groups: individuals who received training as usual (control) and individuals who received an additional 20-h mindfulness-based mind fitness training (MMFT). All subjects completed an IBL task during functional magnetic resonance imaging at baseline and post-MMFT training. Marines who underwent MMFT relative to controls demonstrated a significant attenuation of right anterior insula and ACC during the experience of loaded breathing. These results support the hypothesis that MT changes brain activation such that individuals process more effectively an aversive interoceptive stimulus. Thus, MT may serve as a training technique to modulate the brain's response to negative interoceptive stimuli, which may help to improve resilience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.