ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014
Brain sparing in fetal mice: BOLD MRI and Doppler ultrasound show blood redistribution during hypoxia.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.Immunity · 2021Pooled it
- Effects of gestational intermittent hypoxia on the respiratory system: A tale of the placenta, fetus, and developing offspring.Journal of sleep research · 2025Review
- Altered adult brain morphology in a mouse model of late-onset fetal growth restriction.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Maternal exposure to polyethylene micro- and nanoplastics impairs umbilical blood flow but not fetal growth in pregnant mice.Scientific reports · 2024Article
- A Study of the Literature on Intrauterine Treatment Options for Chronic Placental Insufficiency with Intrauterine Growth Restriction Using Intrauterine Intravascular Amino Acid Supplementation.Life (Basel, Switzerland) · 2023Review
- Sexual dimorphisms in brain gene expression in the growth-restricted guinea pig can be modulated with intra-placental therapy.Pediatric research · 2021Article
- The application ofJournal of developmental origins of health and disease · 2021Review
- Effects of acute mild hypoxia on cerebral blood flow in pilots.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Cerebral Blood Flow Monitoring in High-Risk Fetal and Neonatal Populations.Frontiers in pediatrics · 2021Review
- The clinical value of blood flow parameters of the umbilical artery and middle cerebral artery for assessing fetal distress.American journal of translational research · 2021Article
- Sleep in the Supine Position during Pregnancy Is Associated with Fetal Cerebral Redistribution.Journal of clinical medicine · 2020Article
- Integration and the Developmental Genetics of Allometry.Integrative and comparative biology · 2019Review
- Oxygen-sensitive MRI assessment of tumor response to hypoxic gas breathing challenge.NMR in biomedicine · 2019Article
- Fetal brain sparing in a mouse model of chronic maternal hypoxia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency.Physiological reports · 2018Article
- Ultrasound detection of altered placental vascular morphology based on hemodynamic pulse wave reflection.American journal of physiology. Heart and circulatory physiology · 2017Article
- Ultrasound-guided spectral photoacoustic imaging of hemoglobin oxygenation during development.Biomedical optics express · 2017Article
- MR Imaging-derived Oxygen-Hemoglobin Dissociation Curves and Fetal-Placental Oxygen-Hemoglobin Affinities.Radiology · 2016Article
- Chronic Protein Restriction in Mice Impacts Placental Function and Maternal Body Weight before Fetal Growth.PloS one · 2016Article
- Monitoring brain development of chick embryos in vivo using 3.0 T MRI: subdivision volume change and preliminary structural quantification using DTI.BMC developmental biology · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Mice reproduce many features of human pregnancy and have been widely used to model disorders of pregnancy. However, it has not been known whether fetal mice reproduce the physiologic response to hypoxia known as brain sparing, where blood flow is redistributed to preserve oxygenation of the brain at the expense of other fetal organs. In the present study, blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) and Doppler ultrasound were used to determine the effect of acute hypoxia on the fetal blood flow in healthy, pregnant mice. As the maternal inspired gas mixture was varied between 100% and 8% oxygen on the timescale of minutes, the BOLD signal intensity decreased by 44±18% in the fetal liver and by 12±7% in the fetal brain. Using Doppler ultrasound measurements, mean cerebral blood velocity was observed to rise by 15±8% under hypoxic conditions relative to hyperoxia. These findings are consistent with active regulation of cerebral oxygenation and clearly show brain sparing in fetal mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.