Evidence map›Paper›PMID 24713836›Full record

ReviewAsian journal of andrology

Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer.

Costantine Albany, Noah M Hahn

Open access · goldAbstract readReview
In one paragraph

Review in Asian journal of andrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Prostate cancer and therapeutic challenges.Journal of biological research (Thessalonike, Greece) · 2020
    Review
  5. Article
  6. [Biology behavior of head and neck squamous cell cancer cells changes after knocking down heat shock protein 27].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020
    Article
  7. Article
  8. Article
  9. HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2017
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Costantine Albany
Noah M HahnIndiana University Health, Melvin and Bern Simon Cancer Center, Indianapolis, IN, USA.
Indiana University Health · USIndiana University – Purdue University Indianapolis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defects within apoptotic pathways have been implicated in prostate cancer (PCa) tumorigenesis, metastatic progression and treatment resistance. A hallmark of cancers is the ability to derail apoptosis by inhibiting the apoptotic signal, reducing the expression of apoptotic proteins and/or amplifying survival signals through increased production of antiapoptotic molecule. This review describes associations between heat shock proteins (HSPs) and the human androgen receptor (AR), the role of HSPs and other stress-induced proteins in PCa development and emerging strategies in targeting these protective proteins to treat PCa.

Indexed as

ApoptosisApoptosis Regulatory ProteinsClinical Trials as TopicClusterinHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHumansMaleMolecular ChaperonesProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantProto-Oncogene Proteins c-bcl-2Receptors, AndrogenSignal TransductionApoptosis Regulatory ProteinsAR protein, humanCLU protein, humanClusterinHeat-Shock ProteinsHSP27 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHSPB1 protein, humanMolecular ChaperonesProto-Oncogene Proteins c-bcl-2Receptors, Androgen

Identifiers

PMID24713836
PMCPMC4023360
OpenAlexW1545821454

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.