ArticlePloS one2014
Sample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegata.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Molecular Mechanisms of Venom Diversity.Toxins · 2025Review
- Analysis of multi-disulfide bridges for insulin aspart by stepwise reduction and differentiated alkylation.Analytical and bioanalytical chemistry · 2024Article
- Targeting Dysregulated Ion Channels in Liver Tumors with Venom Peptides.Molecular cancer therapeutics · 2024Review
- Article
- VenomFlow: An Automated Bioinformatic Pipeline for Identification of Disulfide-Rich Peptides from Venom Arsenals.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Diet Diversity in Carnivorous Terebrid Snails Is Tied to the Presence and Absence of a Venom Gland.Toxins · 2021Article
- Cytotoxic and antitumor peptides as novel chemotherapeutics.Natural product reports · 2021Review
- Article
- Macroevolutionary Analyses Suggest That Environmental Factors, Not Venom Apparatus, Play Key Role in Terebridae Marine Snail Diversification.Systematic biology · 2020Article
- Selective Inhibition of Liver Cancer Cells Using Venom Peptide.Marine drugs · 2019Article
- Synthesis of New S-S and C-C Bonds by Photoinitiated Radical Recombination Reactions in the Gas Phase.International journal of mass spectrometry · 2019Article
- Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity.Scientific reports · 2018Article
- Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods.Marine drugs · 2018Review
- New techniques, applications and perspectives in neuropeptide research.The Journal of experimental biology · 2018Review
- Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Small Packages, Big Returns: Uncovering the Venom Diversity of Small Invertebrate Conoidean Snails.Integrative and comparative biology · 2016Article
- Review
- Characterization and Recombinant Expression of Terebrid Venom Peptide from Terebra guttata.Toxins · 2016Article
- Marine Peptides: Bioactivities and Applications.Marine drugs · 2015Review
- Molecular Diversity and Gene Evolution of the Venom Arsenal of Terebridae Predatory Marine Snails.Genome biology and evolution · 2015Article
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Authors and funding
10 authors.
Funding
Abstract
Disulfide-rich peptide toxins found in the secretions of venomous organisms such as snakes, spiders, scorpions, leeches, and marine snails are highly efficient and effective tools for novel therapeutic drug development. Venom peptide toxins have been used extensively to characterize ion channels in the nervous system and platelet aggregation in haemostatic systems. A significant hurdle in characterizing disulfide-rich peptide toxins from venomous animals is obtaining significant quantities needed for sequence and structural analyses. Presented here is a strategy for the structural characterization of venom peptide toxins from sample limited (4 ng) specimens via direct mass spectrometry sequencing, chemical synthesis and NMR structure elucidation. Using this integrated approach, venom peptide Tv1 from Terebra variegata was discovered. Tv1 displays a unique fold not witnessed in prior snail neuropeptides. The novel structural features found for Tv1 suggest that the terebrid pool of peptide toxins may target different neuronal agents with varying specificities compared to previously characterized snail neuropeptides.
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