ArticleEuropean journal of human genetics : EJHG2014
Human active X-specific DNA methylation events showing stability across time and tissues.
Article in European journal of human genetics : EJHG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Sex-influenced DNA methylation differs by placental cell type.Biology of sex differences · 2026Article
- Epigenetic landscape of hormone-independent sexual dimorphism and characterization of canine XIST.Scientific reports · 2025Article
- Leukocyte methylomic imprints of exposure to the genocide against the Tutsi in Rwanda: a pilot epigenome-wide analysis.Epigenomics · 2022Article
- Article
- DNA methylation impact on Fabry disease.Clinical epigenetics · 2021Review
- Article
- Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples.Genome medicine · 2020Article
- Distinct chromatin structures at the monoamine oxidase-A promoter correlate with allele-specific expression in SH-SY5Y cells.Genes, brain, and behavior · 2019Article
- sEst: Accurate Sex-Estimation and Abnormality Detection in Methylation Microarray Data.International journal of molecular sciences · 2018Article
- Dosage compensation and DNA methylation landscape of the X chromosome in mouse liver.Scientific reports · 2018Article
- Allele-specific non-CG DNA methylation marks domains of active chromatin in female mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Recent progress towards understanding the role of DNA methylation in human placental development.Reproduction (Cambridge, England) · 2016Review
- Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.Nature communications · 2016Article
- Discovery of a novel genetic susceptibility locus on X chromosome for systemic lupus erythematosus.Arthritis research & therapy · 2015Article
- Sex differences in DNA methylation assessed by 450 K BeadChip in newborns.BMC genomics · 2015Article
- Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation.Human molecular genetics · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenomenon of X chromosome inactivation in female mammals is well characterised and remains the archetypal example of dosage compensation via monoallelic expression. The temporal series of events that culminates in inactive X-specific gene silencing by DNA methylation has revealed a 'patchwork' of gene inactivation along the chromosome, with approximately 15% of genes escaping. Such genes are therefore potentially subject to sex-specific imbalance between males and females. Aside from XIST, the non-coding RNA on the X chromosome destined to be inactivated, very little is known about the extent of loci that may be selectively silenced on the active X chromosome (Xa). Using longitudinal array-based DNA methylation profiling of two human tissues, we have identified specific and widespread active X-specific DNA methylation showing stability over time and across tissues of disparate origin. Our panel of X-chromosome loci subject to methylation on Xa reflects a potentially novel mechanism for controlling female-specific X inactivation and sex-specific dimorphisms in humans. Further work is needed to investigate these phenomena.
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