Evidence map›Paper›PMID 24713613›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014

Role of dopamine D2 receptors in human reinforcement learning.

Christoph Eisenegger, Michael Naef, Anke Linssen, Luke Clark, Praveen K Gandamaneni, Ulrich Müller, Trevor W Robbins

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

  1. Pooled it
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  7. Dopamine D2 Receptor Modulates Exercise Related Effect on Cortical Excitation/Inhibition and Motor Skill Acquisition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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  8. Methylphenidate undermines or enhances divergent creativity depending on baseline dopamine synthesis capacity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  9. Testosterone eliminates strategic prosocial behavior through impacting choice consistency in healthy males.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  16. Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
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  17. Amplified Striatal Responses to Near-Miss Outcomes in Pathological Gamblers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
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  19. Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Christoph Eisenegger1] Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Cambridge, UK [2] Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University of Vienna, Vienna, Austria.
Michael NaefDepartment of Economics, Royal Holloway, University of London, Egham, UK.
Anke LinssenDepartment of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands.
Luke Clark1] Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Cambridge, UK [2] Department of Psychology, University of Cambridge, Cambridge, UK.
Praveen K GandamaneniDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Ulrich Müller1] Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Cambridge, UK [2] Cambridgeshire & Peterborough NHS Foundation Trust, Adult ADHD Service, Cambridge, UK.
Trevor W Robbins1] Behavioural and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Cambridge, UK [2] Department of Psychology, University of Cambridge, Cambridge, UK.
University of Cambridge · GBMaastricht University · NLRoyal Holloway University of London · GB

Funding

Medical Research Council G0001354Medical Research Council G1000183Wellcome Trust 093875Wellcome Trust 093875/Z/10/Z
6 · The paper itself

Abstract

Influential neurocomputational models emphasize dopamine (DA) as an electrophysiological and neurochemical correlate of reinforcement learning. However, evidence of a specific causal role of DA receptors in learning has been less forthcoming, especially in humans. Here we combine, in a between-subjects design, administration of a high dose of the selective DA D2/3-receptor antagonist sulpiride with genetic analysis of the DA D2 receptor in a behavioral study of reinforcement learning in a sample of 78 healthy male volunteers. In contrast to predictions of prevailing models emphasizing DA's pivotal role in learning via prediction errors, we found that sulpiride did not disrupt learning, but rather induced profound impairments in choice performance. The disruption was selective for stimuli indicating reward, whereas loss avoidance performance was unaffected. Effects were driven by volunteers with higher serum levels of the drug, and in those with genetically determined lower density of striatal DA D2 receptors. This is the clearest demonstration to date for a causal modulatory role of the DA D2 receptor in choice performance that might be distinct from learning. Our findings challenge current reward prediction error models of reinforcement learning, and suggest that classical animal models emphasizing a role of postsynaptic DA D2 receptors in motivational aspects of reinforcement learning may apply to humans as well.

Indexed as

Reinforcement, PsychologyAdultChoice BehaviorDopamine AntagonistsDouble-Blind MethodGenotypeGenotyping TechniquesHumansMaleModels, PsychologicalNeuropsychological TestsPolymorphism, GeneticProlactinReaction TimeReceptors, Dopamine D2Receptors, Dopamine D3Dopamine AntagonistsDRD2 protein, humanProlactinReceptors, Dopamine D2Receptors, Dopamine D3Sulpiride

Identifiers

PMID24713613
PMCPMC4138746
OpenAlexW2036976328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.