ArticleClinical pharmacology and therapeutics2014
Toward enhanced pharmacovigilance using patient-generated data on the internet.
Article in Clinical pharmacology and therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medication-indication knowledge bases: a systematic review and critical appraisal.Journal of the American Medical Informatics Association : JAMIA · 2015Pooled it
- The quality and scope of health information on online drug platforms: a topic modelling and expert evaluation study of a Polish-language forum.Harm reduction journal · 2026Article
- Risk Management of Medication Errors: Improving the Quality of Pharmacotherapeutic Practice.Pharmacology research & perspectives · 2025Article
- Review
- Integrating electronic health records with other data sources for postmarket drug safety signal identification: a review.Frontiers in drug safety and regulation · 2024Review
- Social media and internet search data to inform drug utilization: A systematic scoping review.Frontiers in digital health · 2023Article
- Identifying Actionability as a Key Factor for the Adoption of 'Intelligent' Systems for Drug Safety: Lessons Learned from a User-Centred Design Approach.Drug safety · 2021Article
- Combining Social Media and FDA Adverse Event Reporting System to Detect Adverse Drug Reactions.Drug safety · 2020Article
- Prospective Evaluation of Adverse Event Recognition Systems in Twitter: Results from the Web-RADR Project.Drug safety · 2020Article
- Extraction of Information Related to Drug Safety Surveillance From Electronic Health Record Notes: Joint Modeling of Entities and Relations Using Knowledge-Aware Neural Attentive Models.JMIR medical informatics · 2020Article
- Mining Social Media Data for Biomedical Signals and Health-Related Behavior.Annual review of biomedical data science · 2020Article
- Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use.Drug safety · 2020Article
- Adverse Events Due to Insomnia Drugs Reported in a Regulatory Database and Online Patient Reviews: Comparative Study.Journal of medical Internet research · 2019Article
- Characteristics of Future Models of Integrated Outpatient Care.Healthcare (Basel, Switzerland) · 2019Review
- Challenges in implementing yearly enhanced safety surveillance of influenza vaccination in Europe: lessons learned and future perspectives.Human vaccines & immunotherapeutics · 2019Review
- Web-Based Signal Detection Using Medical Forums Data in France: Comparative Analysis.Journal of medical Internet research · 2018Article
- Utility of social media and crowd-intelligence data for pharmacovigilance: a scoping review.BMC medical informatics and decision making · 2018Article
- Big Data and Pharmacovigilance: Data Mining for Adverse Drug Events and Interactions.P & T : a peer-reviewed journal for formulary management · 2018Article
- Toward multimodal signal detection of adverse drug reactions.Journal of biomedical informatics · 2017Article
- Validation of New Signal Detection Methods for Web Query Log Data Compared to Signal Detection Algorithms Used With FAERS.Drug safety · 2017Article
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5 authors.
Funding
Abstract
The promise of augmenting pharmacovigilance with patient-generated data drawn from the Internet was called out by a scientific committee charged with conducting a review of the current and planned pharmacovigilance practices of the US Food and Drug Administration (FDA). To this end, we present a study on harnessing behavioral data drawn from Internet search logs to detect adverse drug reactions (ADRs). By analyzing search queries collected from 80 million consenting users and by using a widely recognized benchmark of ADRs, we found that the performance of ADR detection via search logs is comparable and complementary to detection based on the FDA's adverse event reporting system (AERS). We show that by jointly leveraging data from the AERS and search logs, the accuracy of ADR detection can be improved by 19% relative to the use of each data source independently. The results suggest that leveraging nontraditional sources such as online search logs could supplement existing pharmacovigilance approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.