ArticleJournal of medicinal food2014
Antioxidant properties of proanthocyanidins attenuate carbon tetrachloride (CCl4)-induced steatosis and liver injury in rats via CYP2E1 regulation.
Article in Journal of medicinal food, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 78 citations in OpenAlex.
- Optimization of Proanthocyanidin Extraction from Grape Seeds Using Response Surface Methodology and Subsequent Evaluation of Its Antioxidant and Immunomodulatory Capacities.Foods (Basel, Switzerland) · 2026Article
- Extraction of grape seeds by different solvents affects the activities of the resultant extract.AMB Express · 2025Article
- Metabolic dysfunction-associated steatotic liver disease-induced changes in the antioxidant system: a review.Archives of toxicology · 2025Review
- Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model.Clinical science (London, England : 1979) · 2024Article
- Assessment of the Antioxidant and Hypolipidemic Properties ofAntioxidants (Basel, Switzerland) · 2024Article
- Effect of Purple Sweet Potato Using Different Cooking Methods on Cytoprotection against Ethanol-Induced Oxidative Damage through Nrf2 Activation in HepG2 Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Pathological Role of Oxidative Stress in Aflatoxin-Induced Toxicity in Different Experimental Models and Protective Effect of Phytochemicals: A Review.Molecules (Basel, Switzerland) · 2023Review
- Nephroprotective Effect of Fennel (Antioxidants (Basel, Switzerland) · 2023Article
- Taraxasterol alleviates fatty acid-induced lipid deposition in calf hepatocytes by decreasing ROS production and endoplasmic reticulum stress.Journal of animal science · 2023Article
- Hepatoprotective Effect of a New FFAR1 Agonist-N-Alkylated Isobornylamine.Molecules (Basel, Switzerland) · 2023Article
- Phenolics and Volatile Compounds of Fennel (Antioxidants (Basel, Switzerland) · 2022Article
- Natural Polyphenols, 1,2,3,4,6-O-Pentagalloyglucose and Proanthocyanidins, as Broad-Spectrum Anticoronaviral Inhibitors Targeting Mpro and RdRp of SARS-CoV-2.Biomedicines · 2022Article
- Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling.Molecular medicine reports · 2022Article
- Tibetan Medicine Shi-Wei-Gan-Ning-San Alleviates Carbon Tetrachloride-Induced Chronic Liver Injury by Inhibiting TGF-Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Antioxidative potential and ameliorative effects of green lentil (Frontiers in nutrition · 2022Article
- Effect of Silymarin and Quercetin in a Miniaturized Scaffold in Wistar Rats against Non-alcoholic Fatty Liver Disease.ACS omega · 2021Article
- DHA Protects Hepatocytes from Oxidative Injury through GPR120/ERK-Mediated Mitophagy.International journal of molecular sciences · 2021Article
- Nutraceutical Properties of Polyphenols against Liver Diseases.Nutrients · 2020Review
- Article
- Effect of procyanidins on lipid metabolism and inflammation in rats exposed to alcohol and iron.Heliyon · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver steatosis is characterized by lipid dysregulation and fat accumulation in the liver and can lead to oxidative stress in liver. Since proanthocyanidins are present in plant-based foods and have powerful antioxidant properties, we investigated whether proanthocyanidins can prevent oxidative stress and subsequent liver injury. Carbon tetrachloride (CCl4) treatment can cause steatosis in rats that models both alcoholic and non-alcoholic fatty liver disease in humans. We pre-treated rats by oral administration of proanthocyanidins extracted from grape seeds 7 days prior to intragastrically administering CCl4. Proanthocyanidin treatment continued for an additional 2 weeks, after which time liver and serum were harvested, and mediators of liver injury, oxidative stress, and histological features were evaluated. CCl4-treated rats exhibited significant increases in the following parameters as compared to non-treated rats: fat droplets in the liver, liver injury (ALT, AST), and DNA damage (8-OHdG). Additionally, CCl4 treatment decreased antioxidant enzymes SOD, GSH, GPX, and CAT in the liver due to their rapid depletion after battling against oxidative stress. Compared to CCl4-treated rats, treatment with proanthocyanidins effectively suppressed lipid accumulation, liver injury, DNA damage, as well as restored antioxidant enzyme levels. Further investigation revealed that proanthocyanidins treatment also inhibited expression of CYP2E1 in liver, which prevented the initial step of generating free radicals from CCl4. The data presented here show that treatment with orally administered proanthocyanidins prevented liver injury in the CCl4-induced steatosis model, likely through exerting antioxidant actions to suppress oxidative stress and inhibiting the free radical-generating CYP2E1 enzyme.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.