Evidence map›Paper›PMID 24711896›Full record

ArticleIranian journal of basic medical sciences2014

Hormonal and metabolic effects of polyunsaturated fatty acid (omega-3) on polycystic ovary syndrome induced rats under diet.

Elaheh Ouladsahebmadarek, Arash Khaki, Sharareh Khanahmadi, Hamidreza Ahmadi Ashtiani, Pooya Paknejad, Mohammad Reza Ayubi

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In one paragraph

Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Elaheh OuladsahebmadarekWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Arash KhakiDepartment of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Sharareh KhanahmadiWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hamidreza Ahmadi AshtianiDepartment of Biochemistry, Islamic Azad University, Pharmaceutical, Tehran, Iran.
Pooya PaknejadWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Reza AyubiDepartment of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Tabriz University of Medical Sciences · IRIslamic Azad University of Tabriz · IRIslamic Azad University, Tehran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OBJECTIVE(S): PCOS (polycystic ovary syndrome) produces symptoms in approximately 5% to 10% of women of reproductive age (12-45 years old). It is thought to be one of the leading causes of female subfertility. This study aimed to confirm the role of nutrition containing omega-3 (polyunsaturated fatty acid) on control of experimental PCO induced by estradiol-valerat in rats. MATERIALS AND

methodsWistar female rats (n=40) were allocated into control (n=10) and test groups (n= 30), test group was subdivided into 3 groups: G1, received omega-3 (240 mg/kg/orally/daily); G2 and G3 groups were induced PCO by single injection of estradiol-valerate (16 mg/kg/IM). Group 3 received omega-3 (240 mg/kg/orally/daily) and low carbohydrate feeding for 60 subsequent days; on sixtieth day 5 ml blood samples and ovarian tissues of all rats in the group were removed and prepared for biochemical and hormonal analysis.

resultsCatalase, GPX (Glutathione peroxidase), SOD (Superoxide dismutase) in groups that received omega-3 showed higher levels, but MDA (malondialdehyde) level was significantly decreased (P<0.05) in comparison with other experimental groups. Ovarian weights in both experimental and control groups were similar (P<0.05). Level of serum FSH (follicle stimulating hormone) was decreased, but level of testosterone was significantly increased (P<0.05) in PCO group in comparison with control and omega-3 groups.

conclusionRESULTS revealed that administration of omega-3 plus lower carbohydrate food significantly controlled   PCO syndrome and balanced FSH and testosterone.

Indexed as

Catalaze (CAT)Follicle stimulating hormone (FSH)Glutathione peroxidase (GPX)Omega-3Polycystic ovary (PCO)Super oxide dismutase (SOD)Testosterone

Identifiers

PMID24711896
PMCPMC3976750
OpenAlexW2130340425

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.