ArticleIranian journal of pharmaceutical research : IJPR2014
Cytotoxic activity of some medicinal plants from hamedan district of iran.
Article in Iranian journal of pharmaceutical research : IJPR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The GenusLife (Basel, Switzerland) · 2023Review
- Evaluation of the Anticancer Potential ofBioMed research international · 2023Article
- A Comparative Study on Anticancer Effects of theEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Anticancer Activity ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
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- Ethyl Acetate Extract of Licorice RootIranian journal of pharmaceutical research : IJPR · 2018Article
- Investigatıon of Antioxıdative, Cytotoxic, Membrane-Damaging and Membrane-Protective Effects of The Essentıal Oil ofIranian journal of pharmaceutical research : IJPR · 2017Article
- Primula auriculata Extracts Exert Cytotoxic and Apoptotic Effects against HT-29 Human Colon Adenocarcinoma Cells.Iranian journal of pharmaceutical research : IJPR · 2016Article
- Antimicrobial Activities of Three Medicinal Plants and Investigation of Flavonoids of Tripleurospermum disciforme.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Article
- Naghibione; A Novel Sesquiterpenoid with Antiplasmodial Effect from Dorema hyrcanum Koso-Pol. Root, a Plant Used in Traditional Medicine.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Antiplasmodial Activity and Cytotoxicity of Plants Used in Traditional Medicine of Iran for the Treatment of Fever.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Cytotoxic and antiproliferative effect of tepary bean lectins on C33-A, MCF-7, SKNSH, and SW480 cell lines.Molecules (Basel, Switzerland) · 2014Article
- A Systematic and Mechanistic Review on the Phytopharmacological Properties ofAncient science of lifeReview
- Cytotoxic effects of hydroalcoholic extract ofAvicenna journal of phytomedicineArticle
- Assessment of the Biological Activity of Thyme Essential Oil in the Presence of the Classic Antibiotic Tetracycline.Current health sciences journalArticle
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Authors and funding
3 authors.
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Abstract
Medicinal plants have been investigated for possible anti-cancer effects. The aim of the present study was to examine the cytotoxic activity of several medicinal plants on different tumor cell lines. 11 selected plant species which have been used in folkloric prescriptions were collected from different sites of Hamedan district of Iran. The methanolic extracts of the plants were prepared and their cytotoxic effects on four human cancer cell lines (A549, human lung adenocarcinoma; MCF7, human breast adenocarcinoma; HepG2, hepatocellular carcinoma and HT-29, human colon carcinoma) and one normal cell line (MDBK, bovine kidney) were examined using the MTT assay. Three of these were exhibited antiproliferative activity against one or more of the cell lines. The extract from Primula auriculata demonstrated the highest cytotoxicity with IC50 of 25.79, 35.79 and 43.34 μg.mL-1 against MCF7, HepG2 and HT- 29 cells, respectively. For some of the plants, their traditional use was correlated with the cytotoxic results, whereas for others the results may support the non-cytotoxicity of species used traditionally as natural remedies. The cytotoxic species could be considered as potential of anticancer compounds.
Indexed as
Identifiers
24711847PMC3977071What OpenQuestion holds
Registered trials
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