ArticleIranian journal of pharmaceutical research : IJPR2014
FTIR-Microspectroscopy Detection of Metronidazole Teratogenic Effects on Mice Fetus.
Article in Iranian journal of pharmaceutical research : IJPR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Conglomerated Imiquimod and Metronidazole Incorporated Biodegradable Nanofibrous Mats for Potential Therapy of Cervical Cancer.International journal of nanomedicine · 2025Article
- Article
- Keratin/Copper Complex Electrospun Nanofibers for Antibacterial Treatments: Property Investigation and In Vitro Response.Materials (Basel, Switzerland) · 2024Article
- Article
- Thermo-Optical Characterization of Therminol55 Based MXene-AlNanomaterials (Basel, Switzerland) · 2022Article
- Evaluation of the hydrogen-rich water alleviation potential on mercury toxicity in earthworms using ATR-FTIR and LC-ESI-MS/MS spectroscopy.Environmental science and pollution research international · 2022Article
- Using least angular regression to model the antibacterial potential of metronidazole complexes.Scientific reports · 2021Article
- Data on the effect of lead concomitant noise on oxidative stress in rats.Data in brief · 2018Article
- Characterization of Miconazole Effects on Mice Fetus Liver Tissue Using FTIR-MSP.Iranian journal of pharmaceutical research : IJPR · 2017Article
- FTIR Biospectroscopy Investigation on Cisplatin Cytotoxicity in Three Pairs of Sensitive and Resistant Cell Line.Iranian journal of pharmaceutical research : IJPR · 2016Article
- FTIR Microspectroscopy Reveals Chemical Changes in Mice Fetus Following Phenobarbital Administration.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Predicting of Effective Dose as Biomarker for Cytotoxicity Using Partial Least Square-Fourier Transform Infrared Spectroscopy (PLS_FTIR).Iranian journal of pharmaceutical research : IJPR · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metronidazole is used to treat trichomoniasis, bacterial vaginosis, and other diseases. There are controversy aspects about its teratogenicity. A teratogenic agent can alter morphology or subsequent function of the fetus. The aim of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by Metronidazole using FTIR micro spectroscopy. The mice were injected with metronidazole (60 mg/Kg) on gestation day 9. Fetuses were dissected on day 15 of gestation and morphological and histological studies on the fetus were carried out. Serial sectioning (10 μm) of normal and metronidazole-treated brains and livers were used for FTIR measurement in the wave number region of 600- 3600 cm(-1).The results showed that there were some variations between the fetus of normal and treated brain and liver. The band intensities in fetus brain and liver of test animals were reduced and shifted at 707 cm(-1), 1155 cm(-1), 1054 cm(-1), 1256 cm(-1) and 1219 cm(-1), 1453 cm(-1) and 1525 cm(-1), 1622 cm(-1), 1645 cm(-1) and 2944 cm(-1),while the band intensities were increased and shifted at 879 cm(-) (1) , 810 cm(-1), 1223 cm(-1), 1256 cm(-1) 1360 cm(-1), 1723 cm(-1). It was concluded that most of variations in brain and liver of Metronidazole treated fetuses are in amid bands, nucleic acid and carbohydrate related bands. Based on these findings FTIR spectroscopy can be a useful tool for bio diagnostic.
Indexed as
Identifiers
24711835PMC3977059W1937498602What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.