ArticleAdvances in pharmacological sciences2014
Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis.
Article in Advances in pharmacological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Review
- Research Advances on Health Effects of EdibleFoods (Basel, Switzerland) · 2020Review
- Hypnotic Effect of Ocimum basilicum on Pentobarbital-Induced Sleep in Mice.Iranian Red Crescent medical journal · 2016Article
- Safety evaluation of Phytovagex, a pessary formulation of Nigella sativa, on pregnant rats.Avicenna journal of phytomedicineArticle
- Potentiating effects ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, there is no report on safety of Artemisia Kopetdaghensis. This study aimed to determine the possible undesirable effects of A. Kopetdaghensis on reproduction of female rats. The pregnant rats were treated (i.p.) with vehicle or 200 and 400 mg/kg of A. Kopetdaghensis hydroalcoholic extract from the 2nd to 8th day of pregnancy. Then, number and weight of neonates, duration of pregnancy, and percent of dead fetuses were determined. Also, cytotoxicity of this plant was tested using fibroblast (L929) and ovary (Cho) cell lines. The A. Kopetdaghensis had no significant effect on duration of pregnancy, average number of neonates, and weight of neonates. However, administration of 200 and 400 mg/kg of the extract led to 30 and 44% abortion in animals, respectively. The extract at concentrations ≥200 μg/mL significantly (P < 0.001) inhibited the proliferation of L929 fibroblast cells. Regarding the Cho cells, the extract induced toxicity only at concentration of 800 μg/mL (P < 0.01). Our results showed that continuous consumption of A. Kopetdaghensis in pregnancy may increase the risk of abortion and also may have toxic effect on some cells.
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Registered trials
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