ReviewFrontiers in plant science2014
The diverse roles of FRO family metalloreductases in iron and copper homeostasis.
Review in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 104 citations in OpenAlex.
- The SVP-FRO6 Module Integrates the Control of Leaf Senescence and Flowering in Arabidopsis.Plant, cell & environment · 2026Article
- Stress drives plasticity in leaf ageing transcriptional dynamics in Arabidopsis thaliana.Nature plants · 2026Article
- Article
- Combating plant diseases through transition metal allocation.The New phytologist · 2025Review
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- The genomics and physiology of abiotic stressors associated with global elevational gradients in Arabidopsis thaliana.The New phytologist · 2024Article
- Genome-Wide Identification of the Ferric Chelate Reductase (Plants (Basel, Switzerland) · 2024Article
- A CYBDOM protein impacts iron homeostasis and primary root growth under phosphate deficiency in Arabidopsis.Nature communications · 2024Article
- Ferric reduction by a CYBDOM protein counteracts increased iron availability in root meristems induced by phosphorus deficiency.Nature communications · 2024Article
- The small iron-deficiency-induced protein OLIVIA and its relation to the bHLH transcription factor POPEYE.PloS one · 2024Article
- Loss of OPT3 function decreases phloem copper levels and impairs crosstalk between copper and iron homeostasis and shoot-to-root signaling in Arabidopsis thaliana.The Plant cell · 2023Article
- Understanding the Mechanisms of Fe Deficiency in the Rhizosphere to Promote Plant Resilience.Plants (Basel, Switzerland) · 2023Review
- Identification and Functional Analysis of Two Mitoferrins, CsMIT1 and CsMIT2, Participating in Iron Homeostasis in Cucumber.International journal of molecular sciences · 2023Article
- Comprehensive Survey of ChIP-Seq Datasets to Identify Candidate Iron Homeostasis Genes Regulated by Chromatin Modifications.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Physiological and Transcriptome Analyses Revealed the Mechanism by Which Deferoxamine Promotes Iron Absorption inInternational journal of molecular sciences · 2022Article
- Integration of the Metabolomic and Transcriptome Analysis Reveals the Remarkable Compounds ofInternational journal of molecular sciences · 2022Article
- Crosstalk Between Iron and Sulfur Homeostasis Networks inFrontiers in plant science · 2022Article
- Plasma membrane phylloquinone biosynthesis in nonphotosynthetic parasitic plants.Plant physiology · 2021Article
- Molecular characterization of Fe-acquisition genes causing decreased Fe uptake and photosynthetic inefficiency in Fe-deficient sunflower.Scientific reports · 2021Article
- Review
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Iron and copper are essential for plants and are important for the function of a number of protein complexes involved in photosynthesis and respiration. As the molecular mechanisms that control uptake, trafficking and storage of these nutrients emerge, the importance of metalloreductase-catalyzed reactions in iron and copper metabolism has become clear. This review focuses on the ferric reductase oxidase (FRO) family of metalloreductases in plants and highlights new insights into the roles of FRO family members in metal homeostasis. Arabidopsis FRO2 was first identified as the ferric chelate reductase that reduces ferric iron-chelates at the root surface-rhizosphere interface. The resulting ferrous iron is subsequently transported across the plasma membrane of root epidermal cells by the ferrous iron transporter, IRT1. Recent work has shown that two other members of the FRO family (FRO4 and FRO5) function redundantly to reduce copper to facilitate its uptake from the soil. In addition, FROs appear to play important roles in subcellular compartmentalization of iron as FRO7 is known to contribute to delivery of iron to chloroplasts while mitochondrial family members FRO3 and FRO8 are hypothesized to influence mitochondrial metal ion homeostasis. Finally, recent studies have underscored the importance of plasma membrane-localized ferric reductase activity in leaves for photosynthetic efficiency. Taken together, these studies highlight a number of diverse roles for FROs in both iron and copper metabolism in plants.
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