ReviewFrontiers in microbiology2014
Trans-translation exposed: understanding the structures and functions of tmRNA-SmpB.
Review in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- Influence of SmpB and ClpX interactions and interactomes on the transcription profile of Mycobacterium tuberculosis.The Biochemical journal · 2026Article
- Direct RNA sequencing of the Escherichia coli epitranscriptome uncovers alterations under heat stress.Nucleic acids research · 2025Article
- Article
- Review
- Safe and easy in vitro evaluation of tmRNA-SmpB-mediatedRNA (New York, N.Y.) · 2021Article
- Widespread ribosome stalling in a genome-reduced bacterium and the need for translational quality control.iScience · 2021Article
- Reassembling green fluorescent protein for in vitro evaluation of trans-translation.Nucleic acids research · 2020Article
- Redefining the Small Regulatory RNA Transcriptome in Streptococcus pneumoniae Serotype 2 Strain D39.Journal of bacteriology · 2019Article
- Article
- The structure of an elongation factor G-ribosome complex captured in the absence of inhibitors.Nucleic acids research · 2018Article
- Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells.ACS infectious diseases · 2017Article
- tRNA-mimicry in IRES-mediated translation and recoding.RNA biology · 2016Review
- Grad-seq guides the discovery of ProQ as a major small RNA-binding protein.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Origins of tmRNA: the missing link in the birth of protein synthesis?Nucleic acids research · 2016Review
- Non-canonical roles of tRNAs and tRNA mimics in bacterial cell biology.Molecular microbiology · 2016Review
- Absence of tmRNA Has a Protective Effect against Fluoroquinolones inFrontiers in microbiology · 2016Article
- Clicking on trans-translation drug targets.Frontiers in microbiology · 2015Article
- Small regulatory RNAs in Streptococcus pneumoniae: discovery and biological functions.Frontiers in genetics · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ribosome stalling is a serious issue for cell survival. In bacteria, the primary rescue system is trans-translation, performed by tmRNA and its protein partner small protein B (SmpB). Since its discovery almost 20 years ago, biochemical, genetic, and structural studies have paved the way to a better understanding of how this sophisticated process takes place at the cellular and molecular levels. Here we describe the molecular details of trans-translation, with special mention of recent cryo-electron microscopy and crystal structures that have helped explain how the huge tmRNA-SmpB complex targets and delivers stalled ribosomes without interfering with canonical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.