ArticleFrontiers in human neuroscience2014
5 Hz repetitive transcranial magnetic stimulation over the ipsilesional sensory cortex enhances motor learning after stroke.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03086551 (Modulating Interaction of Motor Learning Networks in Rehabilitation of Stroke), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulating Interaction of Motor Learning Networks in Rehabilitation of Stroke
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Non-invasive brain stimulation effectively improves post-stroke sensory impairment: a systematic review and meta-analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2023Pooled it
- Effects of Different Repetitive Transcranial Magnetic Stimulation Targets for Enhancing Motor Learning: A Single-Blind Randomized Controlled Trial.Neural plasticity · 2026Trial
- Trial
- Improved processing speed and decreased functional connectivity in individuals with chronic stroke after paired exercise and motor training.Scientific reports · 2023Trial
- Does rTMS Targeting Contralesional S1 Enhance Upper Limb Somatosensory Function in Chronic Stroke? A Proof-of-Principle Study.Neurorehabilitation and neural repair · 2021Trial
- Frequency-specific photobiomodulation at theta and gamma enhances cognitive networks and mitigates age-related decline.GeroScience · 2026Article
- Somatosensory cortex neuronal integrity is altered after stroke.Frontiers in human neuroscience · 2026Article
- Central and peripheral factors moderating pain effects on motor control and disability in chronic lumbosacral radicular pain.Journal of neuroengineering and rehabilitation · 2025Article
- Modern Technologies Supporting Motor Rehabilitation After Stroke: A Narrative Review.Journal of clinical medicine · 2025Review
- Oculomotor learning is evident during implicit motor sequence learning.Scientific reports · 2025Article
- The effect of rTMS intervention with different targets on neural remodeling in stroke patients: a randomized controlled trial.Frontiers in neurology · 2025Article
- Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery.NeuroImage. Clinical · 2025Article
- Implicit motor sequence learning using three-dimensional reaching movements with the non-dominant left arm.Experimental brain research · 2024Article
- Oculomotor functional connectivity associated with motor sequence learning.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Consolidation of Newly Learned Movements Depends upon the Somatosensory Cortex in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Investigating the effects of excitatory and inhibitory somatosensory rTMS on somatosensory functioning in the acute and subacute phases of stroke: a preliminary double-blind and randomized trial.Frontiers in human neuroscience · 2024Article
- Spatial probability maps of the segments of the postcentral sulcus in the human brain.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Sensorimotor performance after high-definition transcranial direct current stimulation over the primary somatosensory or motor cortices in men versus women.Scientific reports · 2022Article
- Continuous theta-burst stimulation modulates resting-state EEG microstates in healthy subjects.Cognitive neurodynamics · 2022Article
- Somatosensory Cortex Repetitive Transcranial Magnetic Stimulation and Associative Sensory Stimulation of Peripheral Nerves Could Assist Motor and Sensory Recovery After Stroke.Frontiers in human neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory feedback is critical for motor learning, and thus to neurorehabilitation after stroke. Whether enhancing sensory feedback by applying excitatory repetitive transcranial magnetic stimulation (rTMS) over the ipsilesional primary sensory cortex (IL-S1) might enhance motor learning in chronic stroke has yet to be investigated. The present study investigated the effects of 5 Hz rTMS over IL-S1 paired with skilled motor practice on motor learning, hemiparetic cutaneous somatosensation, and motor function. Individuals with unilateral chronic stroke were pseudo-randomly divided into either Active or Sham 5 Hz rTMS groups (n = 11/group). Following stimulation, both groups practiced a Serial Tracking Task (STT) with the hemiparetic arm; this was repeated for 5 days. Performance on the STT was quantified by response time, peak velocity, and cumulative distance tracked at baseline, during the 5 days of practice, and at a no-rTMS retention test. Cutaneous somatosensation was measured using two-point discrimination. Standardized sensorimotor tests were performed to assess whether the effects might generalize to impact hemiparetic arm function. The active 5 Hz rTMS + training group demonstrated significantly greater improvements in STT performance {response time [F (1, 286.04) = 13.016, p < 0.0005], peak velocity [F (1, 285.95) = 4.111, p = 0.044], and cumulative distance [F (1, 285.92) = 4.076, p = 0.044]} and cutaneous somatosensation [F (1, 21.15) = 8.793, p = 0.007] across all sessions compared to the sham rTMS + training group. Measures of upper extremity motor function were not significantly different for either group. Our preliminary results suggest that, when paired with motor practice, 5 Hz rTMS over IL-S1 enhances motor learning related change in individuals with chronic stroke, potentially as a consequence of improved cutaneous somatosensation, however no improvement in general upper extremity function was observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.