Evidence map›Paper›PMID 24711745›Full record

ArticleInternational journal of biomedical science : IJBS2014

Topical delivery of vitamin d3: a randomized controlled pilot study.

Mir Sadat-Ali, Dalal A Bubshait, Haifa A Al-Turki, Dakheel A Al-Dakheel, Wissam S Al-Olayani

Registry-linked trialAbstract read
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In one paragraph

Article in International journal of biomedical science : IJBS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02735200 (Topical Delivery of Vitamin D3), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02735200 phase2completednot on this mapstarted 2016, after this paper: background citation

Topical Delivery of Vitamin D3: A Randomized Controlled Trial (RCT)

TypeinterventionalSponsorImam Abdulrahman Bin Faisal UniversityRan2016 to 2016Enrolled550ConditionsVitamin D DeficiencyArmsApplication of topical vitamin d3 (Top-D), Application of Aloe vera gel
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Novel Pharmacological Nonopioid Therapies in Chronic Pain.Current pain and headache reports · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mir Sadat-AliCollege of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.
Dalal A BubshaitCollege of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.
Haifa A Al-TurkiCollege of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.
Dakheel A Al-DakheelCollege of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.
Wissam S Al-OlayaniCollege of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe purpose of the present study is to explore the assessment if the transdermal delivery of vitamin D is feasible.

methodsIn 50 female Medical students, this study was conducted. Age, weight and height was taken, a detailed history and clinical examination was performed. Blood was drawn for 25 Hydroxy Vitamin D3 (25OHD) level. Two women had >30 ng/mL of 25OHD and was excluded from the study. The participants were divided into two groups of 24 in each arm. All participants equivocally agreed not to change their dietary habits and life style till the study was over. The study group of women were asked to apply; Top-D (Aloe Vera based- Vitamin D3) (Patency Pending) was developed at King Fahd Hospital of the University, AlKhobar with each gram of the Top-D cream delivering 5000 IU of vitamin D3. The second group used 1 gram of Aloe vera gel. The participants had no knowledge to which group they belong. A second blood sample was taken at the end of 3 months and the data was analyzed.

resultsThe data of 48 women was available for analysis. The average age was 22.58 ± 1.95 years. The mean pre-treatment 25OHD in the study group was 12.05 ng/Ml ± 6.54 and post-treatment was 37.95 ng/mL ± 6.43 (P=0.001, CI<28.582 ). In control group pre-treatment 25OHD was 11.4 ng/mL ± 3.97 and post-treatment was 10.58ng/mL ± 3.03.

conclusionsThis randomized control study shows that vitamin D3 can safely be delivered through the dermal route. This route could be exploited in treating vitamin D deficiency.

Indexed as

deficiencyMedication Burdenroute of administrationVitamin D

Identifiers

PMID24711745
PMCPMC3976443

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.