ArticleThe Journal of experimental medicine2014
Adjuvant-specific regulation of long-term antibody responses by ZBTB20.
Article in The Journal of experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 70 citations in OpenAlex.
- Insights from adaptive immune regulation for disease resistance breeding in livestock and poultry.Science China. Life sciences · 2026Review
- B-cell DNA methylation signature in response to hepatitis B virus vaccination in females and males.Frontiers in immunology · 2026Article
- Early, adjuvant-responsive epigenetic programs in B cells imprint subsequent plasma cell survival and the duration of humoral immunity.bioRxiv : the preprint server for biology · 2025Article
- Zinc Finger and BTB Domain-Containing 20: A Newly Emerging Player in Pathogenesis and Development of Human Cancers.Biomolecules · 2024Review
- Unraveling the diversity and functions of tissue-resident plasma cells.Nature immunology · 2024Article
- Poly I:C elicits broader and stronger humoral and cellular responses to aFrontiers in immunology · 2024Article
- Review
- Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.Science immunology · 2022Article
- Supplying the trip to antibody production-nutrients, signaling, and the programming of cellular metabolism in the mature B lineage.Cellular & molecular immunology · 2022Review
- Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection.Cell reports · 2021Article
- Biochemical coordination of plasma cell genesis.Immunological reviews · 2021Review
- Epigenetic gene regulation in plasma cells.Immunological reviews · 2021Review
- IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis.Cellular & molecular immunology · 2021Article
- Single-cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse cell types including T-betBMC biology · 2021Article
- AMPKα1 in B Cells Dampens Primary Antibody Responses yet Promotes Mitochondrial Homeostasis and Persistence of B Cell Memory.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- The diagnostic challenges and clinical course of a myeloid/lymphoid neoplasm with eosinophilia andCold Spring Harbor molecular case studies · 2020Article
- ZBTB38 is dispensable for antibody responses.PloS one · 2020Article
- ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges.Scientific reports · 2019Article
- Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating neuroinflammation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- What B cell memories are made of.Current opinion in immunology · 2019Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The duration of antibody production by long-lived plasma cells varies with the type of immunization, but the basis for these differences is unknown. We demonstrate that plasma cells formed in response to the same immunogen engage distinct survival programs depending on the adjuvant. After alum-adjuvanted immunization, antigen-specific bone marrow plasma cells deficient in the transcription factor ZBTB20 failed to accumulate over time, leading to a progressive loss of antibody production relative to wild-type controls. Fetal liver reconstitution experiments demonstrated that the requirement for ZBTB20 was B cell intrinsic. No defects were observed in germinal center numbers, affinity maturation, or plasma cell formation or proliferation in ZBTB20-deficient chimeras. However, ZBTB20-deficient plasma cells expressed reduced levels of MCL1 relative to wild-type controls, and transgenic expression of BCL2 increased serum antibody titers. These data indicate a role for ZBTB20 in promoting survival in plasma cells. Strikingly, adjuvants that activate TLR2 and TLR4 restored long-term antibody production in ZBTB20-deficient chimeras through the induction of compensatory survival programs in plasma cells. Thus, distinct lifespans are imprinted in plasma cells as they are formed, depending on the primary activation conditions. The durability of vaccines may accordingly be improved through the selection of appropriate adjuvants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.