ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Plasma antioxidants, genetic variation in SOD2, CAT, GPX1, GPX4, and prostate cancer survival.
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Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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17citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 12% of its field
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Dietary intake of tomato and lycopene, blood levels of lycopene, and risk of total and specific cancers in adults: a systematic review and dose-response meta-analysis of prospective cohort studies.Frontiers in nutrition · 2025Pooled it
- The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers.Scientific reports · 2016Pooled it
- Pooled it
- Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Trial
- Circulating Antioxidant Levels and Risk of Prostate Cancer by TMPRSS2:ERG.The Prostate · 2017Trial
- Selenium- or Vitamin E-Related Gene Variants, Interaction with Supplementation, and Risk of High-Grade Prostate Cancer in SELECT.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Trial
- The Role of Se-Containing Glutathione Peroxidases and Thioredoxin Reductases in Oncogenesis: Expression Paradoxes and Therapeutic Prospects.Antioxidants (Basel, Switzerland) · 2026Review
- The Association of Polymorphisms in Genes Encoding Antioxidant Enzymes GPX1 (rs1050450), SOD2 (rs4880) and Transcriptional Factor Nrf2 (rs6721961) with the Risk and Development of Prostate Cancer.Medicina (Kaunas, Lithuania) · 2022Article
- Chosen Antioxidant Enzymes GPx4 and GPx8 in Human Colorectal Carcinoma: Study of the Slovak Population.Medicina (Kaunas, Lithuania) · 2022Article
- Roles of ferroptosis in urologic malignancies.Cancer cell international · 2021Review
- The Interaction between Dietary Selenium Intake and Genetics in Determining Cancer Risk and Outcome.Nutrients · 2020Review
- GPX1 Localizes to the Nucleus in Prostate Epithelium and its Levels are not Associated with Prostate Cancer Recurrence.Antioxidants (Basel, Switzerland) · 2018Article
- Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Identification of polymorphisms in cancer patients that differentially affect survival with age.Aging · 2017Article
- A case-control study of selenoprotein genes polymorphisms and autoimmune thyroid diseases in a Chinese population.BMC medical genetics · 2017Article
- Mitochondrial Redox Signaling and Tumor Progression.Cancers · 2016Review
- GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues.European journal of histochemistry : EJH · 2015Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Erin L Van BlariganAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois erin.vanblarigan@ucsf.edu.
Jing MaAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, IllinoisAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
Stacey A KenfieldAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
Meir J StampferAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, IllinoisAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, IllinoisAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
Howard D SessoAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, IllinoisAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
Edward L GiovannucciAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, IllinoisAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, IllinoisAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
John S WitteAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, IllinoisAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
John W ErdmanAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
June M ChanAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, IllinoisAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
Kathryn L PenneyAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, IllinoisAuthors' Affiliations: Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts; and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois.
University of California, San Francisco · USBrigham and Women's Hospital · USHarvard University · US
Funding
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0MPhysicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MTraining in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5MEnergy Balance-Related Hormones & Prostate Cancer Incidence & ProgressionR01CA133891 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI GIOVANNUCCI, EDWARD · 2008 to 2012
$3.3MGrowth Factors and Lethal Prostate Cancer SignatureR01CA141298 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI STAMPFER, MEIR · 2010 to 2013
$2.2MTraining in the Molecular & Genetic Epidemiology of CancerT32CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, IONA C, ZIV, ELAD · 2020 to 2024
$1.8MProstate Microenvironmental & Prostate Cancer ProgressionR01CA106947 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAN, JUNE ML · 2006 to 2009
$1.5MRANDOMIZED TRIAL OF ASPIRIN AND MORTALITYR01CA040360 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 2002
$775kTRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'SR01HL034595 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 1991
–NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA097193NCI NIH HHS R01 CA106947NCI NIH HHS R01 CA133891NCI NIH HHS R01 CA141298NCI NIH HHS R25 CA112355NCI NIH HHS T32 CA112355NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA167552NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595
Abstract
backgroundAntioxidants may reduce risk of aggressive prostate cancer, and single-nucleotide polymorphisms (SNP) in antioxidant genes may modify this association.
methodsWe used Cox proportional hazards regression to examine circulating prediagnostic α-tocopherol, γ-tocopherol, and lycopene; SNPs in SOD2 (n = 5), CAT (n = 6), GPX1 (n = 2), GPX4, (n = 3); and their interactions and risk of lethal prostate cancer among 2,439 men with nonmetastatic prostate cancer in the Health Professionals Follow-up Study and Physicians' Health Study.
resultsWe observed 223 events over a median follow-up of 10 years. Higher α-tocopherol levels were associated with lower risk of lethal prostate cancer [HR 3rd versus 1st quartile (Q): 0.51; 95% confidence interval (CI), 0.30-0.89; HR 4th versus 1st Q: 0.68; 95% CI, 0.41-1.13; P trend: 0.02]. Men homozygous for the less common allele (G) at rs3746165 in GPX4 had a 35% lower risk of lethal prostate cancer compared with men homozygous for the more common allele (A; HR, 0.65; 95% CI, 0.43-0.99). Among men homozygous for the less common allele in rs3746165, high γ-tocopherol levels were associated with a 3.5-fold increased risk of lethal prostate cancer (95% CI, 1.27-9.72; P value, 0.02; interaction P value, 0.01).
conclusionsAmong men with nonmetastatic prostate cancer, higher circulating prediagnostic α-tocopherol may be associated with lower risk of developing lethal disease. Variants in GPX4 may be associated with risk of lethal prostate cancer, and may modify the relation between γ-tocopherol and prostate cancer survival. IMPACT: Circulating tocopherol levels and variants in GPX4 may affect prostate cancer progression. Cancer Epidemiol Biomarkers Prev; 23(6); 1037-46. ©2014 AACR.
Indexed as
AgedAntioxidantsCatalaseCohort StudiesDisease ProgressionGenotypeGlutathione PeroxidaseGlutathione Peroxidase GPX1HumansMaleMolecular EpidemiologyPhospholipid Hydroperoxide Glutathione PeroxidasePolymorphism, Single NucleotideProspective StudiesProstatic NeoplasmsSuperoxide DismutaseAntioxidantsCatalaseCAT protein, humanGlutathione PeroxidaseGlutathione Peroxidase GPX1GPX1 protein, humanPhospholipid Hydroperoxide Glutathione PeroxidaseSuperoxide DismutaseSuperoxide Dismutase 2
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