ArticleProceedings of the National Academy of Sciences of the United States of America2014
Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Canonical Notch2 signaling regulates development and maintenance of iron-recycling macrophages and iron homeostasis.Nature communications · 2026Article
- Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte-to-DC Differentiation Via Microbiota-Associated IAA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tissue-resident colon macrophages shape the microbiome and regulate mucosal healing via ferroportin.Cell reports · 2026Article
- RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation.Genes & diseases · 2026Review
- Macrophages in intestinal homeostasis and inflammatory bowel disease.Nature reviews. Gastroenterology & hepatology · 2023Review
- Article
- The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.The Journal of experimental medicine · 2020Article
- Commensal microbiota drive the functional diversification of colon macrophages.Mucosal immunology · 2020Article
- Gut macrophages: key players in intestinal immunity and tissue physiology.Current opinion in immunology · 2020Review
- Intestinal Macrophages in Resolving Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.PLoS biology · 2019Article
- Origin, Differentiation, and Function of Intestinal Macrophages.Frontiers in immunology · 2018Review
- Notch Signaling in Macrophages in the Context of Cancer Immunity.Frontiers in immunology · 2018Review
- SIRPαProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling.Mucosal immunology · 2017Article
- Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.Nature communications · 2016Article
- Transcriptional Control of Dendritic Cell Development.Annual review of immunology · 2016Review
- Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-κB crosstalk.Oncotarget · 2015Article
- Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy.The Journal of biological chemistry · 2015Article
- Breast Milk and Solid Food Shaping Intestinal Immunity.Frontiers in immunology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gastrointestinal tract comes into direct contact with environmental agents, including bacteria, viruses, and foods. Intestine-specific subsets of immune cells maintain gut homeostasis by continuously sampling luminal antigens and maintaining immune tolerance. CD11c(+)CX3CR1(+) cells sample luminal antigens in the small intestine and contribute to the trafficking of bacteria to lymph nodes under dysbiotic conditions. The molecular mechanisms crucial for the differentiation of CD11c(+)CX3CR1(+) cells remain unclear. Here we demonstrate that the Notch1- or Notch2-Rbpj axis is essential for the development of CD11c(+)CX3CR1(+) cells. In mice in which Rbpj or Notch1 and Notch2 were deleted from CD11c(+) cells, there was a deficit of CD11c(+)CX3CR1(+) cells and an accumulation of CD11c(low)CX3CR1(+) cells. The CD11c(low)CX3CR1(+) cells could not differentiate to CD11c(+)CX3CR1(+) cells, suggesting that CD11c(low)CX3CR1(+) cells represent a lineage distinct from CD11c(+)CX3CR1(+) cells. These data indicate that Notch signaling is essential for lineage fixation of intestinal CD11c(+)CX3CR1(+) cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.