ArticleProceedings of the National Academy of Sciences of the United States of America2014
Damage to insula abolishes cognitive distortions during simulated gambling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Internet addiction-induced brain structure and function alterations: a systematic review and meta-analysis of voxel-based morphometry and resting-state functional connectivity studies.Brain imaging and behavior · 2023Pooled it
- Opioid Antagonists for Pharmacological Treatment of Gambling Disorder: Are they Relevant?Current neuropharmacology · 2018Pooled it
- The Effect of Losses Disguised as Wins and Near Misses in Electronic Gaming Machines: A Systematic Review.Journal of gambling studies · 2017Pooled it
- Positive Illusions: The Role of Cognitive Distortions Related to Gambling and Temporal Perspective in Chasing Behavior.Journal of gambling studies · 2022Trial
- Inducing illusory control ensures persistence when rewards fade and when others outperform us.Psychonomic bulletin & review · 2020Trial
- Amplified Striatal Responses to Near-Miss Outcomes in Pathological Gamblers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Conative inference as a mechanism of allostatic resilience: wanting to be and being to want.Cognitive, affective & behavioral neuroscience · 2026Review
- Cognitive Distortions and Alexithymia: A Cross-Sectional Study of Their Association.Healthcare (Basel, Switzerland) · 2026Article
- Classifying athletes and non-athletes by differences in spontaneous brain activity: a machine learning and fMRI study.Brain structure & function · 2025Article
- Computational and Neural Evidence for Altered Fast and Slow Learning from Losses in Problem Gambling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Resting-State Functional Connectivity Profile of Insular Subregions.Brain sciences · 2024Article
- Reduced grey matter volume in adolescents with conduct disorder: a region-of-interest analysis using multivariate generalized linear modeling.Discover mental health · 2023Article
- Reduced Grey Matter Volume in Adolescents with Conduct Disorder: A Region-of-Interest Analysis Using Multivariate Generalized Linear Modeling.Research square · 2023Article
- Individuals with problem gambling and obsessive-compulsive disorder learn through distinct reinforcement mechanisms.PLoS biology · 2023Article
- How distinct functional insular subdivisions mediate interacting neurocognitive systems.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Testing the effect of high-definition transcranial direct current stimulation of the insular cortex to modulate decision-making and executive control.Frontiers in behavioral neuroscience · 2023Article
- Stress-altering anterior insular cortex activity affects risk decision-making behavior in mice of different sexes.Frontiers in cellular neuroscience · 2023Article
- Neural cue-reactivity in pathological gambling as evidence for behavioral addiction: a systematic review.Current psychology (New Brunswick, N.J.) · 2022Article
- Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting.NeuroImage. Clinical · 2022Article
- Atypical interoception as a common risk factor for psychopathology: A review.Neuroscience and biobehavioral reviews · 2021Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Gambling is a naturalistic example of risky decision-making. During gambling, players typically display an array of cognitive biases that create a distorted expectancy of winning. This study investigated brain regions underpinning gambling-related cognitive distortions, contrasting patients with focal brain lesions to the ventromedial prefrontal cortex (vmPFC), insula, or amygdala ("target patients") against healthy comparison participants and lesion comparison patients (i.e., with lesions that spare the target regions). A slot machine task was used to deliver near-miss outcomes (i.e., nonwins that fall spatially close to a jackpot), and a roulette game was used to examine the gambler's fallacy (color decisions following outcome runs). Comparison groups displayed a heightened motivation to play following near misses (compared with full misses), and manifested a classic gambler's fallacy effect. Both effects were also observed in patients with vmPFC and amygdala damage, but were absent in patients with insula damage. Our findings indicate that the distorted cognitive processing of near-miss outcomes and event sequences may be ordinarily supported by the recruitment of the insula. Interventions to reduce insula reactivity could show promise in the treatment of disordered gambling.
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