ArticleNucleic acids research2014
Bacteriophage λ N protein inhibits transcription slippage by Escherichia coli RNA polymerase.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Nascent RNA profiling reveals genome-wide productive reiterative initiation regulating gene transcription in bacteria.Nucleic acids research · 2025Article
- Engineering bacteriophages for enhanced host range and efficacy: insights from bacteriophage-bacteria interactions.Frontiers in microbiology · 2023Review
- Low-level expression of the Type II restriction-modification system confers potent bacteriophage resistance in Escherichia coli.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- Transcription fidelity: New paradigms in epigenetic inheritance, genome instability and disease.DNA repair · 2019Review
- Non-programmed transcriptional frameshifting is common and highly RNA polymerase type-dependent.Microbial cell factories · 2018Article
- Article
- Transcription elongation.Transcription · 2017Review
- Structural basis for λN-dependent processive transcription antitermination.Nature microbiology · 2017Article
- Probing the structure of Nun transcription arrest factor bound to RNA polymerase.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- N protein from lambdoid phages transforms NusA into an antiterminator by modulating NusA-RNA polymerase flap domain interactions.Nucleic acids research · 2015Article
- Regulation of transcription elongation and termination.Biomolecules · 2015Review
- Bacteriophage lambda: Early pioneer and still relevant.Virology · 2015Review
- Productive mRNA stem loop-mediated transcriptional slippage: Crucial features in common with intrinsic terminators.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Transcriptional frameshifting rescues Citrobacter rodentium type VI secretion by the production of two length variants from the prematurely interrupted tssM gene.PLoS genetics · 2014Article
- The presence of an RNA:DNA hybrid that is prone to slippage promotes termination by T7 RNA polymerase.Journal of molecular biology · 2014Article
- Transcription start site sequence and spacing between the -10 region and the start site affect reiterative transcription-mediated regulation of gene expression in Escherichia coli.Journal of bacteriology · 2014Article
- Transcription regulation mechanisms of bacteriophages: recent advances and future prospects.BioengineeredReview
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Transcriptional slippage is a class of error in which ribonucleic acid (RNA) polymerase incorporates nucleotides out of register, with respect to the deoxyribonucleic acid (DNA) template. This phenomenon is involved in gene regulation mechanisms and in the development of diverse diseases. The bacteriophage λ N protein reduces transcriptional slippage within actively growing cells and in vitro. N appears to stabilize the RNA/DNA hybrid, particularly at the 5' end, preventing loss of register between transcript and template. This report provides the first evidence of a protein that directly influences transcriptional slippage, and provides a clue about the molecular mechanism of transcription termination and N-mediated antitermination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.