Evidence map›Paper›PMID 24711167›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2014

The P3 event-related potential is a biomarker for the efficacy of vagus nerve stimulation in patients with epilepsy.

Leen De Taeye, Kristl Vonck, Marlies van Bochove, Paul Boon, Dirk Van Roost, Lies Mollet, Alfred Meurs, Veerle De Herdt, Evelien Carrette, Ine Dauwe and 4 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06970444 (The Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Auditory Processing Abilities in Healthy Individuals), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06970444 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Auditory Processing Abilities in Healthy Individuals

TypeinterventionalSponsorMedipol UniversityRan2023 to 2024Enrolled70ConditionsCentral Auditory Disease, Auditory Processing Disorder, Central, Auditory Processing Disorders, Vagus Nerve StimulationArmstranscutaneous auricular vagus nerve stimulation (taVNS), Sham device
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Electroencephalogram and heart rate variability features as predictors of responsiveness to vagus nerve stimulation in patients with epilepsy: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
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  14. Neurostimulation treatments for epilepsy: Deep brain stimulation, responsive neurostimulation and vagus nerve stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Leen De TaeyeLCEN3, Department of Neurology, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium, Leen.detaeye@Ugent.be.
Kristl Vonck
Marlies van Bochove
Paul Boon
Dirk Van Roost
Lies Mollet
Alfred Meurs
Veerle De Herdt
Evelien Carrette
Ine Dauwe
Stefanie Gadeyne
Pieter van Mierlo
Tom Verguts
Robrecht Raedt
Ghent University Hospital · BEGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, the mechanism of action of vagus nerve stimulation (VNS) is not fully understood, and it is unclear which factors determine a patient's response to treatment. Recent preclinical experiments indicate that activation of the locus coeruleus noradrenergic system is critical for the antiepileptic effect of VNS. This study aims to evaluate the effect of VNS on noradrenergic signaling in the human brain through a noninvasive marker of locus coeruleus noradrenergic activity: the P3 component of the event-related potential. We investigated whether VNS differentially modulates the P3 component in VNS responders versus VNS nonresponders. For this purpose, we recruited 20 patients with refractory epilepsy who had been treated with VNS for at least 18 months. Patients were divided into 2 groups with regard to their reduction in mean monthly seizure frequency: 10 responders (>50 %) and 10 nonresponders (≤50 %). Two stimulation conditions were compared: VNS OFF and VNS ON. In each condition, the P3 component was measured during an auditory oddball paradigm. VNS induced a significant increase of the P3 amplitude at the parietal midline electrode, in VNS responders only. In addition, logistic regression analysis showed that the increase of P3 amplitude can be used as a noninvasive indicator for VNS responders. These results support the hypothesis that activation of the locus coeruleus noradrenergic system is associated with the antiepileptic effect of VNS. Modulation of the P3 amplitude should be further investigated as a noninvasive biomarker for the therapeutic efficacy of VNS in patients with refractory epilepsy.

Indexed as

Event-Related Potentials, P300Vagus Nerve StimulationAdultBiomarkersCerebral CortexElectroencephalographyEpilepsyFemaleHumansMaleMiddle AgedTreatment OutcomeBiomarkers

Identifiers

PMID24711167
PMCPMC4121454
OpenAlexW1976236137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.