ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2015
Improvement in outcomes after implantation of a novel polyurethane meniscal scaffold for the treatment of medial meniscus deficiency.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 4 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- No differences in clinical outcome between CMI and Actifit meniscal scaffolds: a systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Pooled it
- Are the Biological and Biomechanical Properties of Meniscal Scaffolds Reflected in Clinical Practice? A Systematic Review of the Literature.International journal of molecular sciences · 2019Pooled it
- Similar clinical outcomes following collagen or polyurethane meniscal scaffold implantation: a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Pooled it
- Polyurethane meniscal scaffolds lead to better clinical outcomes but worse articular cartilage status and greater absolute meniscal extrusion.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Pooled it
- Clinical Outcomes of Meniscal Replacement for Meniscus Deficiency: A Systematic Review of Current Evidence.Orthopaedic journal of sports medicine · 2025Review
- Clinical outcomes of artificial meniscus scaffolds for partial meniscus injury: a systematic review and meta-analysis.Knee surgery & related research · 2025Review
- Muscle strength but not balance improves after arthroscopic biodegradable polyurethane meniscus scaffold application.Musculoskeletal surgery · 2022Observational
- Biosynthetic scaffolds for partial meniscal loss: A systematic review from animal models to clinical practice.Bioactive materials · 2021Review
- Meniscal scaffold for the treatment of partial meniscal defect-clinical and radiological outcomes in a two-year follow-up.International orthopaedics · 2021Article
- Meniscal substitution, a developing and long-awaited demand.Journal of experimental orthopaedics · 2020Review
- Implantation of an Actifit® Polyurethane Meniscal Scaffold 18 Months After Subtotal Lateral Meniscectomy in a 13-Year-Old Male Adolescent.The American journal of case reports · 2020Article
- Ongoing MRI remodeling 3-7 years after collagen meniscus implantation in stable knees.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- [Research progress of scaffold materials for tissue engineered meniscus].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Article
- Medial meniscal extrusion: a validation study comparing different methods of assessment.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Article
- Tissue Engineering of Large Full-Size Meniscus Defects by a Polyurethane Scaffold: Accelerated Regeneration by Mesenchymal Stromal Cells.Stem cells international · 2018Article
- Polyurethane-based cell-free scaffold for the treatment of painful partial meniscus loss.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- MR-Imaging of Meniscal Substitution.Journal of the Belgian Society of Radiology · 2016Article
- Mechanical Stimulation Increases Knee Meniscus Gene RNA-level Expression in Adipose-derived Stromal Cells.Plastic and reconstructive surgery. Global open · 2016Article
- Midterm follow-up after implantation of a polyurethane meniscal scaffold for segmental medial meniscus loss: maintenance of good clinical and MRI outcome.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Article
- Comparative Study of Collagen versus Synthetic-Based Meniscal Scaffolds in Treating Meniscal Deficiency in Young Active Population.Cartilage · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMeniscal injury resulting in segmental loss of meniscal tissue is a major risk factor for the development of osteoarthritis. Tissue engineering strategies have provided scaffolds for meniscal regeneration in order to establish a treatment option for patients with limited opportunities for meniscal reconstruction. The purpose of this study was to assess the clinical and magnetic resonance imaging (MRI) results 2 years after implantation of a polyurethane scaffold for chronic segmental medial meniscus deficiency following partial medial meniscectomy.
methodsEighteen patients were treated with arthroscopic implantation of an ActiFit(®) (Orteq Sports Medicine) polyurethane meniscal scaffold for meniscus deficiency of the medial meniscus. Patients were followed up at 6, 12, and 24 months. Clinical outcome was assessed using patient-reported outcome scores (KOOS, KSS, UCLA activity scale, VAS for pain). Radiological outcome was assessed using MRI at 6, 12, and 24 months by evaluating scaffold morphology, scaffold integration, and additional joint injury, as well as joint inflammation.
resultsEighteen patients with a median age of 32.5 years (range 17-49) were enrolled. Statistically significant improvements were present in all patients, but one at 2 years compared to baseline in all categories. Complete resorption of the scaffold occurred in one patient representing a failure to treatment. MRI showed abnormal signal intensity of the scaffold when compared to residual meniscal tissue but without synovitis or joint inflammation. Extrusion of the scaffold was present in four patients. No correlation between scaffold extrusion and clinical outcome was observed.
conclusionArthroscopic implantation of a polyurethane meniscal scaffold in patients with chronic segmental medial meniscus deficiency is not only a safe procedure but leads to good clinical results at a 2-year follow-up. Scaffold extrusion did not appear to affect clinical outcome. LEVEL OF EVIDENCE: IV.
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