Evidence map›Paper›PMID 24710815›Full record

ReviewIEEE transactions on bio-medical engineering2014

The past, present, and future of real-time control in cellular electrophysiology.

Jennifer A Bauer, Katherine M Lambert, John A White

Abstract readReview
In one paragraph

Review in IEEE transactions on bio-medical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Injection of IFrontiers in physiology · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer A Bauer
Katherine M Lambert
John A White

Funding

Real-time control system for biological experimentsR01EB016407 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHRISTINI, DAVID J. · 2013 to 2016
$2.7M
Calcium Signaling in a Model of Temporal Lobe EpilepsyR01NS078331 · NINDS · UNIVERSITY OF UTAH · PI WHITE, JOHN A., WILCOX, KAREN S · 2012 to 2016
$2.0M
Synchronous Activity in Hybrid Neuronal MicrocircuitsR01MH085074 · NIMH · UNIVERSITY OF UTAH · PI WHITE, JOHN A. · 2010 to 2014
$1.7M
NIBIB NIH HHS R01 EB016407NIMH NIH HHS R01 MH085074NINDS NIH HHS R01 NS078331
6 · The paper itself

Abstract

For over 60 years, real-time control has been an important technique in the study of excitable cells. Two such control-based technologies are reviewed here. First, voltage-clamp methods revolutionized the study of excitable cells. In this family of techniques, membrane potential is controlled, allowing one to parameterize a powerful class of models that describe the voltage-current relationship of cell membranes simply, flexibly, and accurately. Second, dynamic-clamp methods allow the addition of new, "virtual" membrane mechanisms to living cells. Dynamic clamp allows researchers unprecedented ways of testing computationally based hypotheses in biological preparations. The review ends with predictions of how control-based technologies will be improved and adapted for new uses in the near future.

Indexed as

Cell Physiological PhenomenaElectrophysiologyPatch-Clamp TechniquesAnimalsCell LineHumansSignal Processing, Computer-Assisted

Identifiers

PMID24710815
PMCPMC4086259

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.