ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2014
Integrated PET/MRI for planning navigated biopsies in pediatric brain tumors.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- A systematic review evaluating the effectiveness of nuclear medicine techniques in enhancing the diagnostic accuracy of stereotactic brain biopsies.Neurosurgical review · 2025Pooled it
- Update on the Use of PET/MRI Contrast Agents and Tracers in Brain Oncology: A Systematic Review.International journal of nanomedicine · 2022Pooled it
- Hybrid Positron Emission Tomography and Magnetic Resonance Imaging Guided Microsurgical Management of Glial Tumors: Case Series and Review of the Literature.Diagnostics (Basel, Switzerland) · 2024Article
- International EANM-SNMMI-ISMRM consensus recommendation for PET/MRI in oncology.European journal of nuclear medicine and molecular imaging · 2023Article
- Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [European journal of nuclear medicine and molecular imaging · 2022Article
- Article
- Deep Learning Based Attenuation Correction of PET/MRI in Pediatric Brain Tumor Patients: Evaluation in a Clinical Setting.Frontiers in neuroscience · 2018Article
- Response assessment of bevacizumab therapy in GBM with integrated 11C-MET-PET/MRI: a feasibility study.European journal of nuclear medicine and molecular imaging · 2017Article
- Neurologic Applications of PET/MR Imaging.Magnetic resonance imaging clinics of North America · 2017Review
- Clinical PET/MRI in neurooncology: opportunities and challenges from a single-institution perspective.Clinical and translational imaging · 2017Review
- Stereotactic biopsy of brainstem lesions: 21 years experiences of a single center.Journal of neuro-oncology · 2016Article
- Positron emission tomography of high-grade gliomas.Journal of neuro-oncology · 2016Review
- Simultaneous 11C-Methionine Positron Emission Tomography/Magnetic Resonance Imaging of Suspected Primary Brain Tumors.PloS one · 2016Article
- Combined PET/MR: The Real Work Has Just Started. Summary Report of the Third International Workshop on PET/MR Imaging; February 17-21, 2014, Tübingen, Germany.Molecular imaging and biology · 2015Article
- Intraoperative neurosonography revisited: effective neuronavigation in pediatric neurosurgery.Ultrasonography (Seoul, Korea) · 2015Review
- Current status and future role of brain PET/MRI in clinical and research settings.European journal of nuclear medicine and molecular imaging · 2015Review
- [11C]-methionine positron emission tomography in the evaluation of pediatric low-grade gliomas.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAn integrated PET/MRI scanner has been used in selected cases of pediatric brain tumor patients to obtain additional metabolic information about lesions for preoperative biopsy planning and navigation. PATIENTS AND
methodsFour patients, age 9-16 years, received PET/MRI scans employing [(11)C]methionine positron emission tomography (PET) and contrast-enhanced 3D-MR sequences for neuronavigation. PET and MR sequences have been matched for neurosurgical guidance. An infrared camera-based neuronavigation system was employed with co-registered MR and PET images fused to hybrid images for preoperative planning, stereotactic biopsy planning, and/or intraoperative guidance.
resultsAll patients showed hot spots of increased amino acid transport in PET and contrast-enhancing lesions in MRI. In three of the four patients, PET hot spots were congruent with contrast-enhancing areas in MRI. In two patients, frame-based stereotactic biopsies were taken from thalamo-mesencephalic lesions. One patient underwent second-look surgery for the suspicion of recurrent malignant glioma of the posterior fossa. One incidental frontal mass lesion was subtotally resected. No complications occurred. Hybrid imaging was helpful during the procedures to obtain representative histopathologic specimens and for surgical guidance during resection. Co-registered images did match with intraoperative landmarks, tumor borders, and histopathologic specimens.
conclusionThe integrated PET/MRI scanner offers co-registered multimodal, high-resolution data for neuronavigation with reduced radiation exposure compared to PET/CT scans. One examination session provides all necessary data for neuronavigation and preoperative planning, avoiding additional anesthesia in the small patients. Hybrid multimodality imaging may improve safety and yield additional information when obtaining representative histopathologic specimens of brain tumors.
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