ArticleThe American journal of tropical medicine and hygiene2014
Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi.
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Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21citing papers in PubMed, 1 pooled it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Technological advances in the serological diagnosis of Chagas disease in dogs and cats: a systematic review.Parasites & vectors · 2022Pooled it
- Trial
- Evaluation of four chimeric Trypanosoma cruzi recombinant antigens for serological diagnosis of chronic Chagas disease in dogs: a phase II study.Parasites & vectors · 2025Article
- K-mer-based approach for serodiagnostic antigen discovery in Chagas disease using unassembled sequencing reads.PLoS neglected tropical diseases · 2025Article
- Rapid High-Sensitivity Detection of Antibodies to Trypanosoma cruzi With a Recombinant Tc24 Antigen-Based Magneto-Immunoassay: A Pilot Study.The Journal of infectious diseases · 2025Article
- Comparison of Four Chimeric Antigens and Commercial Serological Assays for the Diagnosis of Trypanosoma cruzi Infection.The American journal of tropical medicine and hygiene · 2025Article
- A multicentre comparative study of serological methods for diagnosing Chagas disease in Brazil.Memorias do Instituto Oswaldo Cruz · 2025Article
- Diversity of Chagas disease diagnostic antigens: Successes and limitations.PLoS neglected tropical diseases · 2024Review
- Western blot using Trypanosoma cruzi chimeric recombinant proteins for the serodiagnosis of chronic Chagas disease: A proof-of-concept study.PLoS neglected tropical diseases · 2022Article
- Assessing antibody decline after chemotherapy of early chronic Chagas disease patients.Parasites & vectors · 2021Article
- Stability Assessment of Four Chimeric Proteins for Human Chagas Disease Immunodiagnosis.Biosensors · 2021Article
- Use of a Latent Class Analysis in the Diagnosis of Chronic Chagas Disease in the Washington Metropolitan Area.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Glycosylation of Trypanosoma cruzi TcI antigen reveals recognition by chagasic sera.Scientific reports · 2020Article
- Development of a New Lateral Flow Assay Based on IBMP-8.1 and IBMP-8.4 Chimeric Antigens to Diagnose Chagas Disease.BioMed research international · 2020Article
- Article
- Immune reactivity to Trypanosoma cruzi chimeric proteins for Chagas disease diagnosis in immigrants living in a non-endemic setting.BMC infectious diseases · 2019Article
- Highly Accurate Chimeric Proteins for the Serological Diagnosis of Chronic Chagas Disease: A Latent Class Analysis.The American journal of tropical medicine and hygiene · 2018Article
- Severity of Chagasic Cardiomyopathy Is Associated With Response to a Novel Rapid Diagnostic Test for Trypanosoma cruzi TcII/V/VI.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Treatment of Chagas Disease in the United States.Current treatment options in infectious diseases · 2018Review
- Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Diana L MartinCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú hzx3@cdc.gov.
Morgan MarksCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Gerson Galdos-CardenasCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Robert H GilmanCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Brook GoodhewCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Lisbeth FerrufinoCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Anthony HalperinCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Gerardo SanchezCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Manuela VerasteguiCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Patricia EscalanteCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Cesar NaquiraCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Michael Z LevyCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
Caryn BernCenters for Disease Control and Prevention, Atlanta, Georgia; National Institutes of Health, Bethesda, Maryland; Johns Hopkins University, Baltimore, Maryland; Hospital Universitario Japones, Santa Cruz, Bolivia; Asociación Benéfica PRISMA, Lima, Peru; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Arequipa Ministry of Health, Arequipa, Peru; University of Pennsylvania, Philadelphia, Pennsylvania; Universidad Peruana Cayetano Heredia, Lima, Perú
National Institutes of Health · USJohns Hopkins University · USMinistry of Health · PEUniversidad Peruana Cayetano Heredia · PEUniversity of California, San Francisco · US
Funding
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6MThe ecology and epidemiology of Chagas disease in urban and rural communitiesP50AI074285 · NIAID · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI NAQUIRA, CESAR GABRIEL · 2007 to 2011
$3.2MFIC NIH HHS R24 TW007988Medical Research Council MR/K007467/1NIAID NIH HHS P50 AI074285
Abstract
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T. cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-γ (IFNγ)-secreting cells from Peruvian samples. However, the magnitude of the IFNγ response was similar among the IFNγ responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses.
Indexed as
AdultAntibodies, ProtozoanBoliviaChagas DiseaseFemaleGeographyHumansInterferon-gammaMaleMiddle AgedPeruSensitivity and SpecificitySerologic TestsT-LymphocytesTrypanosoma cruziAntibodies, ProtozoanInterferon-gamma
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.