Trial reportThe American journal of tropical medicine and hygiene2014
Sustained clearance of Mansonella ozzardi infection after treatment with ivermectin in the Brazilian Amazon.
Trial report in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Phase III Clinical Trial to Evaluate Ivermectin in the Reduction ofThe American journal of tropical medicine and hygiene · 2018Trial
- High Levels of Community Support for Mansonellosis Interventions in an Endemic Area of the Brazilian Amazon.Tropical medicine and infectious disease · 2025Article
- Broadening the range of use cases for ivermectin - a review of the evidence.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022Review
- An Overview of the Management of Mansonellosis.Research and reports in tropical medicine · 2021Review
- In Silico Identification of Novel Biomarkers and Development of New Rapid Diagnostic Tests for the Filarial Parasites Mansonella perstans and Mansonella ozzardi.Scientific reports · 2019Article
- CD39 and immune regulation in a chronic helminth infection: The puzzling case of Mansonella ozzardi.PLoS neglected tropical diseases · 2018Article
- Sensitivity of diagnostic methods for Mansonella ozzardi microfilariae detection in the Brazilian Amazon Region.Memorias do Instituto Oswaldo Cruz · 2018Article
- Mansonellosis: current perspectives.Research and reports in tropical medicine · 2018Review
- Article
- Mansonella ozzardi: a neglected New World filarial nematode.Pathogens and global health · 2016Review
- A field trial of a PCR-based Mansonella ozzardi diagnosis assay detects high-levels of submicroscopic M. ozzardi infections in both venous blood samples and FTA card dried blood spots.Parasites & vectors · 2015Article
- Mansonelliasis, a neglected parasitic disease in Haiti.Memorias do Instituto Oswaldo Cruz · 2014Review
- Detection ofTherapeutic advances in infectious diseaseArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of Lábrea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.