Evidence map›Paper›PMID 24710037›Full record

ArticleNature communications2014

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status.

Byung Cheon Lee, Alaattin Kaya, Siming Ma, Gwansu Kim, Maxim V Gerashchenko, Sun Hee Yim, Zhen Hu, Lawrence G Harshman, Vadim N Gladyshev

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers.

0numbers the graph read from it
0cells of the map it votes in
163citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

163 citing papers in PubMed, 279 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Methionine restriction and mimetics to ameliorate human aging and disease.Trends in endocrinology and metabolism: TEM · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Gut metabolism links precision nutrition, exercise, and healthspan inbioRxiv : the preprint server for biology · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Byung Cheon LeeDivision of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Alaattin KayaDivision of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Siming MaDivision of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Gwansu KimDepartment of Statistics, Korea University, Seoul 136-701, South Korea.
Maxim V GerashchenkoDivision of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Sun Hee YimDivision of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Zhen HuSchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA.
Lawrence G HarshmanSchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Harvard University · USHarvard University Press · USUniversity of Nebraska–Lincoln · USStatistics Korea · KR

Funding

Methionine sulfoxide reduction, selenium and agingR01AG021518 · NIA · UNIVERSITY OF NEBRASKA LINCOLN · PI GLADYSHEV, VADIM N. · 2003 to 2018
$5.0M
Understanding the Causes of AgingR01AG038004 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2010 to 2013
$1.1M
NIA NIH HHS AG021518NIA NIH HHS AG038004NIA NIH HHS R01 AG021518NIA NIH HHS R01 AG038004
6 · The paper itself

Abstract

Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction extends lifespan in both fruit flies and yeast, and that this effect requires low amino-acid status. Met restriction in Drosophila mimicks the effect of dietary restriction and is associated with decreased reproduction. However, under conditions of high amino-acid status, Met restriction is ineffective and the trade-off between longevity and reproduction is not observed. Overexpression of InRDN or Tsc2 inhibits lifespan extension by Met restriction, suggesting the role of TOR signalling in the Met control of longevity. Overall, this study defines the specific roles of Met and amino-acid imbalance in aging and suggests that Met restiction is a general strategy for lifespan extension.

Indexed as

Caloric RestrictionDrosophila melanogasterLongevityAgingAmino AcidsAnimalsCell Cycle ProteinsDietary ProteinsDrosophila ProteinsFeeding BehaviorFemaleMaleMethionineReceptor Protein-Tyrosine KinasesReproductionSaccharomyces cerevisiaeAmino AcidsCell Cycle ProteinsDietary ProteinsDrosophila Proteinsgig protein, DrosophilaInR protein, DrosophilaMethionineReceptor Protein-Tyrosine Kinasestarget of rapamycin protein, DrosophilaTOR Serine-Threonine Kinases

Identifiers

PMID24710037
PMCPMC4350766
OpenAlexW2139669573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.