ArticleGenes2010
Next generation DNA sequencing and the future of genomic medicine.
Article in Genes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 93 citations in OpenAlex.
- Estimating Postmortem Interval of Buried Pig Carcasses by Integrating Microbial Succession Patterns with Machine Learning Algorithms.Microorganisms · 2025Article
- Next generation sequencing and beyond: a review of genomic sequencing methods.Functional & integrative genomics · 2025Article
- Cell2Read: an automated workflow to generate sequencing-ready DNA libraries from human cell suspensions.Biology methods & protocols · 2025Article
- Estimating postmortem interval based on oral microbial community succession in rat cadavers.Heliyon · 2024Article
- Revealing the Mysteries of Acute Myeloid Leukemia: From Quantitative PCR through Next-Generation Sequencing and Systemic Metabolomic Profiling.Journal of clinical medicine · 2022Review
- Evaluation of serverless computing for scalable execution of a joint variant calling workflow.PloS one · 2021Article
- Capacity Building of Health Professionals on Genetics and Genomics Practice: Evaluation of the Effectiveness of a Distance Learning Training Course for Italian Physicians.Frontiers in genetics · 2021Article
- Article
- Discovering myeloid cell heterogeneity in the lung by means of next generation sequencing.Military Medical Research · 2019Review
- Translational Application of Circulating DNA in Oncology: Review of the Last Decades Achievements.Cells · 2019Review
- Biological Rationale for Targeting MEK/ERK Pathways in Anti-Cancer Therapy and to Potentiate Tumour Responses to Radiation.International journal of molecular sciences · 2019Review
- Metabolomics Analysis of Mesenchymal Stem Cells.International journal of molecular and cellular medicine · 2019Review
- Metabolic follow-up of a Croatian patient with gyrate atrophy and a new mutation in theBiochemia medica · 2018Article
- Pool deconvolution approach for high-throughput gene mining from Bacillus thuringiensis.Applied microbiology and biotechnology · 2018Article
- Biomarkers of Duchenne muscular dystrophy: current findings.Degenerative neurological and neuromuscular disease · 2018Review
- Anaplastic Lymphoma Kinase Testing: IHC vs. FISH vs. NGS.Current treatment options in oncology · 2017Review
- The liquid biopsy in lung cancer.Genes & cancer · 2016Review
- Decoding transcriptional enhancers: Evolving from annotation to functional interpretation.Seminars in cell & developmental biology · 2016Review
- Next Generation Sequencing Technologies: The Doorway to the Unexplored Genomics of Non-Model Plants.Frontiers in plant science · 2015Review
- Plant exomics: concepts, applications and methodologies in crop improvement.Plant signaling & behavior · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the years since the first complete human genome sequence was reported, there has been a rapid development of technologies to facilitate high-throughput sequence analysis of DNA (termed "next-generation" sequencing). These novel approaches to DNA sequencing offer the promise of complete genomic analysis at a cost feasible for routine clinical diagnostics. However, the ability to more thoroughly interrogate genomic sequence raises a number of important issues with regard to result interpretation, laboratory workflow, data storage, and ethical considerations. This review describes the current high-throughput sequencing platforms commercially available, and compares the inherent advantages and disadvantages of each. The potential applications for clinical diagnostics are considered, as well as the need for software and analysis tools to interpret the vast amount of data generated. Finally, we discuss the clinical and ethical implications of the wealth of genetic information generated by these methods. Despite the challenges, we anticipate that the evolution and refinement of high-throughput DNA sequencing technologies will catalyze a new era of personalized medicine based on individualized genomic analysis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.