ArticleGenes2010
An Examination of KCNE1 Mutations and Common Variants in Chronic Tinnitus.
Article in Genes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Functional Profiling ofCirculation. Genomic and precision medicine · 2025Article
- Association Analysis of Candidate Gene Polymorphisms and Tinnitus in Young Musicians.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2021Article
- Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank.Scientific reports · 2021Article
- The Mediating Effect of Psychological Distress on the Association between BDNF, 5-HTTLPR, and Tinnitus Severity.Psychiatry investigation · 2021Article
- Association of Genetic vs Environmental Factors in Swedish Adoptees With Clinically Significant Tinnitus.JAMA otolaryngology-- head & neck surgery · 2019Article
- Genes important for otoneurological diagnostic purposes - current status and future prospects.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2018Review
- A Pilot Genome-Wide Association Study Identifies Potential Metabolic Pathways Involved in Tinnitus.Frontiers in neuroscience · 2017Article
- Genetics of Tinnitus: Time to Biobank Phantom Sounds.Frontiers in genetics · 2017Article
- Genetics of Tinnitus: Still in its Infancy.Frontiers in neuroscience · 2017Review
- Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development.Frontiers in neuroscience · 2016Review
- A KCNE1 missense variant (V47I) causing exercise-induced long QT syndrome (Romano Ward).International journal of cardiology · 2012Article
- Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus.Behavioral and brain functions : BBF · 2011Article
- Analysis of Studies in Tinnitus-Related Gene Research.Noise & healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic tinnitus is a highly prevalent and often incapacitating condition frequently associated with sensorineural hearing loss. While its etiology remains incompletely understood there is a growing awareness of genetic factors that predispose to, or aggravate chronic tinnitus. Candidate genes for the disorder include KCNE1, a potassium channel subunit gene that has been implicated in maturation defects of central vestibular neurons, in Menière's disease, and in noise-induced hearing loss. 201 Caucasian outpatients with a diagnosis of chronic tinnitus were systematically screened for mutations in the KCNE1 open reading frame and in the adjacent sequence by direct sequencing. Allele frequencies were determined for 46 known variants, plus two novel KCNE1 mutations. These comprised one missense substitution (V47I) in the highly conserved region encoding the KCNE1 transmembrane domain, and one rare variant in the gene's 3'UTR. When genotypes were grouped assuming dominance of the minor alleles, no significant genotype or compound genotype effects were observed on tinnitus severity. The newly identified V47I substitution argues in favor of an enlarged spectrum of mutations in hearing disorders. However, with regard to allele frequencies in healthy control populations from earlier studies, more common KCNE1 variants are unlikely to play a major role in chronic tinnitus. Further investigations are invited to address variation in additional channel subunits as possible risk factors in tinnitus.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.