ArticleNature communications2014
Cell wall precursors are required to organize the chlamydial division septum.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
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- Non-essentiality of canonical cell division genes in the planctomycete Planctopirus limnophila.Scientific reports · 2020Article
- ChlamDB: a comparative genomics database of the phylum Chlamydiae and other members of the Planctomycetes-Verrucomicrobiae-Chlamydiae superphylum.Nucleic acids research · 2020Article
- Cultivation and functional characterization of 79 planctomycetes uncovers their unique biology.Nature microbiology · 2020Article
- Interactions Screenings Unearth Potential New Divisome Components in theMicroorganisms · 2019Article
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- Identification of new DNA-associated proteins from Waddlia chondrophila.Scientific reports · 2019Article
Corrections and comments
- Erratum issuedViollier, Patrick [corrected to Viollier, Patrick H]
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the Chlamydiales order are major bacterial pathogens that divide at mid-cell, without a sequence homologue of the FtsZ cytokinetic tubulin and without a classical peptidoglycan cell wall. Moreover, the spatiotemporal mechanisms directing constriction in Chlamydia are not known. Here we show that the MreB actin homologue and its conserved regulator RodZ localize to the division furrow in Waddlia chondrophila, a member of the Chlamydiales order implicated in human miscarriage. RodZ is recruited to the septal site earlier than MreB and in a manner that depends on biosynthesis of the peptidoglycan precursor lipid II by the MurA enzyme. By contrast, crosslinking of lipid II peptides by the Pbp3 transpeptidase disperses RodZ from the septum. Altogether, these findings provide a cytological framework for understanding chlamydial cytokinesis driven by septal cell wall synthesis.
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