Evidence map›Paper›PMID 24709837›Full record

ArticlePloS one2014

High incidence of ischemic stroke occurrence in irradiated lung cancer patients: a population-based surgical cohort study.

Shih-Kai Hung, Moon-Sing Lee, Wen-Yen Chiou, Ching-Chih Lee, Yi-Chun Chen, Chun-Liang Lai, Nai-Chuan Chien, Wen-Lin Hsu, Dai-Wei Liu, Yu-Chieh Su and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Ischemic Stroke in Patients with Cancer: a Retrospective Cross-Sectional Study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2021
    Article
  7. Review
  8. Review
  9. Article
  10. Article
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  12. Article
  13. (18)F-FDG PET imaging in detection of radiation-induced vascular disease in lymphoma survivors.American journal of nuclear medicine and molecular imaging · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shih-Kai HungDepartments of Radiation Oncology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Moon-Sing LeeDepartments of Radiation Oncology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Wen-Yen ChiouDepartments of Radiation Oncology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Ching-Chih LeeDepartment of Otolaryngology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Yi-Chun ChenDivision of Nephrology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Chun-Liang LaiDivision of Chest Medicine, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Nai-Chuan ChienDivision of Thoracic Surgery, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Wen-Lin HsuDepartment of Radiation Oncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Dai-Wei LiuDepartment of Radiation Oncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Yu-Chieh SuDivision of Hematology-Oncology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Szu-Chi LiDivision of Hematology-Oncology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Hung-Chih LaiDivision of Hematology-Oncology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
Shiang-Jiun TsaiDepartments of Radiation Oncology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC.
Feng-Chun HsuDepartments of Radiation Oncology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC.
Hon-Yi LinDepartments of Radiation Oncology, Buddhist Dalin Tzu Chi Hospital, Taiwan, ROC; School of Medicine, Tzu Chi University, Hualien, Taiwan, ROC; Institute of Molecular Biology, National Chung Cheng University, Min-Hsiung, Chia-Yi, Taiwan, ROC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeA high risk of stroke occurrence has been reported in several types of irradiated cancer patients. However, clinical data are lacking in irradiated lung cancer patients. The present study intended to explore a risk level of ischemic stroke occurrence in irradiated lung cancer patients.

methodsA nationwide population-based database obtained from the Taiwan National Health Insurance was analyzed. Between 2003 and 2006, we recruited 560 resected lung cancer patients into two study groups: surgery-plus-irradiation (n = 112) and surgery-alone (n = 448). Patients treated with chemotherapy were excluded. Propensity score match was used for pairing cases with a ratio of 1∶4. Two-year ischemic-stroke-free survival was defined as the primary endpoint.

resultsThree observations supported a high risk of ischemic stroke occurrence in patients with postoperative irradiation when compared with those patients with surgery alone: first, a high incidence per 1,000 person-year (22.3 versus 11.2, 1.99 folds); second, a low two-year ischemic-stroke-free survival rate (92.2% versus 98.1%, P = 0.019); and third, a high adjusted hazard ratio (HR, 4.19; 95% CI, 1.44-12.22; P = 0.009). More notably, the highest risk of ischemic stroke occurrence was found in irradiated patients who had diabetes mellitus (HR, 34.74; 95% CI, 6.35->100; P<0.0001).

conclusionsA high incidence of ischemic stroke was observed in irradiated lung cancer patients, especially in those with diabetes mellitus. For these patients, close clinical surveillance and strict diabetes control should be considered. Further studies to define detail biological mechanisms are encouraged.

Indexed as

AdultAgedBrain IschemiaCohort StudiesDiabetes ComplicationsEndpoint DeterminationFemaleHumansIncidenceLung NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoplasm StagingPostoperative PeriodRadiation Injuries

Identifiers

PMID24709837
PMCPMC3978039

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.