Trial reportPloS one2014
Umbilical cord milking improves transition in premature infants at birth.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of Umbilical Cord Milking Versus Immediate Cord Clamping on Systemic Blood Flow in Premature Infants
The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 9. Neonatal resuscitation.Clinical and experimental emergency medicine · 2026Guideline
- Pooled it
- Interventions to minimize blood loss in very preterm infants-A systematic review and meta-analysis.PloS one · 2021Pooled it
- Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.The Cochrane database of systematic reviews · 2019Pooled it
- Cardiac and cerebral hemodynamics with umbilical cord milking compared with early cord clamping: A randomized cluster crossover trial.Early human development · 2023Trial
- Umbilical cord milking in nonvigorous infants: a cluster-randomized crossover trial.American journal of obstetrics and gynecology · 2023Trial
- The effect of umbilical cord milking on cerebral blood flow in very preterm infants: a randomized controlled study.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Early Cardiac and Cerebral Hemodynamics with Umbilical Cord Milking Compared with Delayed Cord Clamping in Infants Born Preterm.The Journal of pediatrics · 2020Trial
- Timing of umbilical cord clamping among infants born at 22 through 27 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2016Trial
- Article
- Impact of the Neonatal Resuscitation Video Review program for neonatal staff: a qualitative analysis.Pediatric research · 2025Article
- Oxygenation associated with cord management strategies among preterm infants <32 weeks gestation during the transition period.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Application of desirability of outcome ranking to the milking in non-vigorous infants trial.Early human development · 2024Article
- [Interpretation of 2023 American Heart Association and American Academy of Pediatrics focused update on neonatal resuscitation guidelines].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Lung aeration reduces blood pressure surges caused by umbilical cord milking in preterm lambs.Frontiers in pediatrics · 2023Article
- Umbilical cord milking-benefits and risks.Frontiers in pediatrics · 2023Review
- Placental transfusion during neonatal resuscitation in an asphyxiated preterm model.Pediatric research · 2022Article
- Article
- Umbilical cord milking reduces the risk of intraventricular hemorrhage in preterm infants born before 32 weeks of gestation.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Placental Transfusion for Asphyxiated Infants.Frontiers in pediatrics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUmbilical cord milking (UCM) improves blood pressure and urine output, and decreases the need for transfusions in comparison to immediate cord clamping (ICC). The immediate effect of UCM in the first few minutes of life and the impact on neonatal resuscitation has not been described.
methodsWomen admitted to a tertiary care center and delivering before 32 weeks gestation were randomized to receive UCM or ICC. A blinded analysis of physiologic data collected on the newborns in the delivery room was performed using a data acquisition system. Heart rate (HR), SpO2, mean airway pressure (MAP), and FiO2 in the delivery room were compared between infants receiving UCM and infants with ICC.
results41 of 60 neonates who were enrolled and randomized had data from analog tracings at birth. 20 of these infants received UCM and 21 had ICC. Infants receiving UCM had higher heart rates and higher SpO2 over the first 5 minutes of life, were exposed to less FiO2 over the first 10 minutes of life than infants with ICC.
conclusionsUCM when compared to ICC had decreased need for support immediately following delivery, and in situations where resuscitation interventions were needed immediately, UCM has the advantage of being completed in a very short time to improve stability following delivery.
trial registrationClinicalTrials.gov NCT01434732.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.