ArticleJournal of occupational and environmental medicine2014
Genetic variants in the major histocompatibility complex class I and class II genes are associated with diisocyanate-induced Asthma.
Article in Journal of occupational and environmental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The genetics of occupational asthma development among workers exposed to diisocyanates: A systematic literature review with meta-analysis.Frontiers in genetics · 2022Pooled it
- Reduced Isocyanate Release Using a Waterproof, Resin-Based Cast Alternative Relative to Fiberglass Casts.Toxics · 2023Article
- Identification of candidate aberrant differentially methylated/expressed genes in asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Epigenetic Markers Are Associated With Differences in Isocyanate Biomarker Levels in Exposed Spray-Painters.Frontiers in genetics · 2021Article
- Influence of Genetic Variance on Biomarker Levels After Occupational Exposure to 1,6-Hexamethylene Diisocyanate Monomer and 1,6-Hexamethylene Diisocyanate Isocyanurate.Frontiers in genetics · 2020Article
- Genetic variants with gene regulatory effects are associated with diisocyanate-induced asthma.The Journal of allergy and clinical immunology · 2018Article
- Opportunities and obstacles in translating evidence to policy in occupational asthma.Annals of epidemiology · 2018Article
- Biomarkers in Occupational Asthma.Current allergy and asthma reports · 2016Review
- Article
- Genome-Wide Association Study Identifies Novel Loci Associated With Diisocyanate-Induced Occupational Asthma.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Chronic Beryllium Disease: revealing the role of beryllium ion and small peptides binding to HLA-DP2.PloS one · 2014Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA).
methodsThe study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels.
resultsThe HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively).
conclusionThese results suggest that genetic variations within HLA genes play a role in DA risk.
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Registered trials
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