ReviewNature reviews. Endocrinology2014
Pros and cons of GnRHa treatment for early puberty in girls.
Review in Nature reviews. Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Metabolic changes in children with idiopathic central precocious puberty after gonadotrophin-releasing hormone agonist therapy: a meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update.Acta bio-medica : Atenei Parmensis · 2023Pooled it
- An updated meta-analysis of the relationship between vitamin D levels and precocious puberty.Frontiers in endocrinology · 2023Pooled it
- Pooled it
- Serum inhibin B concentration as a predictor of age at first menstruation in girls with idiopathic central precocious puberty.PloS one · 2018Trial
- Anastrozole plus leuprorelin in early maturing girls with compromised growth: the "GAIL" study.Journal of endocrinological investigation · 2016Trial
- The Role of Pelvic Ultrasound in Monitoring and Predicting Therapeutic Efficacy of GnRHa for Central Precocious Puberty.Journal of clinical ultrasound : JCU · 2026Article
- Central Precocious Puberty in Williams Syndrome: Two Cases Illustrating Diagnostic Challenges and Individualized Management.Clinical case reports · 2026Article
- Analysis of pubertal height gain in post-menarche girls.Medicine · 2026Article
- Magnetic resonance imaging-based adenohypophyseal volume for diagnosing hypothalamic-pituitary-gonadal axis activation in pre- and at-puberty children.Quantitative imaging in medicine and surgery · 2026Article
- Article
- Growth Assessment and Nutritional Status in Children with Congenital Adrenal Hyperplasia-A Cross-Sectional Study from a Vietnamese Tertiary Pediatric Center.Diagnostics (Basel, Switzerland) · 2025Article
- GnRH and Cognition.Endocrinology · 2025Review
- Gonadotropin-releasing hormone analogs treatment in girls with central precocious puberty and early fast puberty.Pediatric research · 2024Observational
- Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Clinical Management and Therapy of Precocious Puberty in the Sapienza University Pediatrics Hospital of Rome, Italy.Children (Basel, Switzerland) · 2023Review
- Clinical applications of gonadotropin-releasing hormone analogues: a broad impact on reproductive medicine.F&S reports · 2023Article
- Central precocious puberty in Prader-Willi syndrome: a narrative review.Frontiers in endocrinology · 2023Review
- The effect of metformin on low birth weight girls with precocious puberty: A protocol for systematic review and meta-analysis.Medicine · 2022Article
- Reduction in pediatric growth hormone deficiency and increase in central precocious puberty diagnoses during COVID 19 pandemics.Italian journal of pediatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The timing of puberty has considerable biological, psychosocial and long-term health implications. Secular trends in age at pubertal development, the effects of obesity and the potential effects of environmental endocrine disruptors challenge the standard definitions of precocious puberty and the indications for intervention with gonadotropin-releasing hormone agonists (GnRHa) in girls with precocious puberty. GnRHa therapy is effective in improving adult height in patients who present with classic central precocious puberty (at <8 years old), without causing adverse effects on body composition, BMD and reproductive function. However, its benefits in patients with atypical forms of early puberty not driven by luteinising hormone are not well defined. The role of GnRHa in these patients and the potential benefits in terms of later growth, psychosocial functioning and long-term risk of adult diseases that are associated with early menarche, such as breast cancer and the metabolic syndrome, have not been established.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.