Trial reportJournal of dentistry for children (Chicago, Ill.)
Cluster-randomized xylitol toothpaste trial for early childhood caries prevention.
Trial report in Journal of dentistry for children (Chicago, Ill.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Topical fluoride-antibacterial agent combined therapy versus topical fluoride monotherapy in preventing dental caries: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2020Pooled it
- Xylitol-containing products for preventing dental caries in children and adults.The Cochrane database of systematic reviews · 2015Pooled it
- Addition of Povidone-Iodine to Fluoride Varnish for Dental Caries: A Randomized Clinical Trial.JDR clinical and translational research · 2021Trial
- Effects of xylitol impregnated toothbrushes on periodontal status and microbial flora in orthodontic patients.The Angle orthodontist · 2020Trial
- Efficacy evaluation of an anti-caries varnish: protocol for a phase II randomised controlled trial.BMJ open · 2017Trial
- Milk Sweetened with Xylitol: A Proof-of-Principle Caries Prevention Randomized Clinical Trial.Journal of dentistry for children (Chicago, Ill.) · 2016Trial
- Comparative Evaluation of Antimicrobial Activity and Minimum Inhibitory Concentration of Commercially Available Pediatric Dentifrices: AnInternational journal of clinical pediatric dentistry · 2024Article
- A Short Review of the Toxicity of Dentifrices-Zebrafish Model as a Useful Tool in Ecotoxicological Studies.International journal of molecular sciences · 2023Review
- Anti-racist approaches to increase access to general and oral health care during a pandemic in the Pacific Islander community.Journal of public health dentistry · 2022Article
- Caries Preventive Effects of Theobromine Containing Toothpaste on Early Childhood Caries: Preliminary Results.Acta stomatologica Croatica · 2021Article
- Anti-Bacterial and Anti-Inflammatory Effects of Toothpaste with Swiss Medicinal Herbs towards Patients Suffering from Gingivitis and Initial Stage of Periodontitis: from Clinical Efficacy to Mechanisms.Dentistry journal · 2020Article
- Chair-side saliva parameters assessment and caries experience evaluation.Medicine and pharmacy reports · 2019Review
- Fluorides and Other Preventive Strategies for Tooth Decay.Dental clinics of North America · 2018Review
- Developmental delays and dental caries in low-income preschoolers in the USA: a pilot cross-sectional study and preliminary explanatory model.BMC oral health · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purpose of this study was to assess the efficacy of supervised tooth-brushing with xylitol toothpaste to prevent early childhood caries (ECC) and reduce mutans streptococci.
methodsIn this cluster-randomized efficacy trial, 196 four- to five-year-old children in four Head Start classrooms in the Marshall Islands were randomly assigned to supervised toothbrushing with 1,400 ppm/31 percent fluoride xylitol or 1,450 ppm fluoride sorbitol toothpaste. We hypothesized that there would be no difference in efficacy between the two types of toothpaste. The primary outcome was the surface-level primary molar caries increment (d(2-3)mfs) after six months. A single examiner was blinded to classroom assignments. Two classrooms were assigned to the fluoride-xylitol group (85 children), and two classrooms were assigned to the fluoride-sorbitol group (83 children). The child-level analyses accounted for clustering.
resultsThere was no difference between the two groups in baseline or end-of-trial mean d(2-3)mfs. The mean d(2-3)mfs increment was greater in the fluoride-xylitol group compared to the fluoride-sorbitol group (2.5 and 1.4 d(2-3)mfs, respectively), but the difference was not significant (95% confidence interval: -0.17, 2.37; P=.07). No adverse effects were reported.
conclusionAfter six months, brushing with a low-strength xylitol/fluoride tooth-paste is no more efficacious in reducing ECC than a fluoride-only toothpaste in a high caries-risk child population.
Indexed as
Identifiers
24709430PMC4000539W40426444What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.