Evidence map›Paper›PMID 24709260›Full record

ArticleAntimicrobial agents and chemotherapy2014

Luliconazole demonstrates potent in vitro activity against dermatophytes recovered from patients with onychomycosis.

Nathan P Wiederhold, Annette W Fothergill, Dora I McCarthy, Amir Tavakkol

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Rising antifungal resistance inFrontiers in microbiology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Molecular study and antifungal susceptibility profile ofIranian journal of microbiology · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Emergence of Terbinafine ResistantInfection and drug resistance · 2020
    Article
  12. LowCurrent medical mycology · 2020
    Article
  13. Review
  14. Antifungal drug susceptibility profile of clinically important dermatophytes and determination of point mutations in terbinafine-resistant isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Article
  15. Antimicrobial agents and chemotherapy · 2018
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nathan P WiederholdThe University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Annette W FothergillThe University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Dora I McCarthyThe University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Amir TavakkolTopica Pharmaceuticals, Inc., Los Altos, California, USA atavakkol@topicapharma.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The in vitro activities of luliconazole, amorolfine, ciclopirox, and terbinafine were determined against 320 dermatophyte isolates from large toenails of onychomycosis patients enrolled into an ongoing phase 2b/3 clinical study. The geometric mean MIC for luliconazole was 0.00022 μg/ml against all isolates, compared to 0.0194 to 0.3107 μg/ml for the three other agents. The in vitro potency of luliconazole was maintained regardless of the dermatophyte species.

Indexed as

Antifungal AgentsArthrodermataceaeCiclopiroxDermatomycosesHumansImidazolesMicrobial Sensitivity TestsMorpholinesNaphthalenesOnychomycosisPyridonesTerbinafineamorolfineAntifungal AgentsCiclopiroxImidazolesluliconazoleMorpholinesNaphthalenesPyridonesTerbinafine

Identifiers

PMID24709260
PMCPMC4068440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.