ReviewDevelopmental and comparative immunology2015
Botryllus schlosseri allorecognition: tackling the enigma.
Review in Developmental and comparative immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Closed Systems for Long-Term Propagation of the Marine TunicateLife (Basel, Switzerland) · 2026Article
- Regulated cell death in fungi from a comparative immunology perspective.Cell death and differentiation · 2026Review
- Article
- Histocompatibility in Botryllus schlosseri and the origins of adaptive immunity.Immunogenetics · 2025Review
- The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality.Nature communications · 2025Article
- First chromosome-level genome assembly of the colonial chordate model Botryllus schlosseri (Tunicata).GigaScience · 2025Article
- Genotype-specific Expression of Uncle Fester Suggests a Role in Allorecognition Education in a Basal Chordate.Integrative and comparative biology · 2024Article
- Genetic and functional diversity of allorecognition receptors in the urochordate,bioRxiv : the preprint server for biology · 2024Article
- Genotype-specific expression ofbioRxiv : the preprint server for biology · 2024Article
- Genomic view of the origins of cell-mediated immunity.Immunogenetics · 2023Article
- Multiple Alr genes exhibit allorecognition-associated variation in the colonial cnidarian Hydractinia.Immunogenetics · 2022Article
- Innate Immunity Mechanisms in Marine Multicellular Organisms.Marine drugs · 2022Review
- Methodological Approaches To Assess Innate Immunity and Innate Memory in Marine Invertebrates and Humans.Frontiers in toxicology · 2022Review
- Establishment of the immunological self in juvenileFrontiers in immunology · 2022Article
- The Onset of Whole-Body Regeneration inFrontiers in cell and developmental biology · 2022Article
- Review
- Review
- Sequence Diversity, Locus Structure, and Evolutionary History of theFrontiers in immunology · 2021Article
- Evolution of Allorecognition in the Tunicata.Biology · 2020Review
- Kin recognition: Neurogenomic response to mate choice and sib mating avoidance in a parasitic wasp.PloS one · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Allorecognition has been well-studied in the context of vertebrate adaptive immunity and recognition of the Major Histocompatibility Complex (MHC), which is the central event of vertebrate immune responses. Although allorecognition systems have been identified throughout the metazoa, recent results have shown that there is no apparent conservation or orthologous relationship between the mechanisms underlying this phenomenon in different organisms. Thus the origin of the vertebrate adaptive immune system as well as these other complex recognition systems is a complete mystery. This review will focus on allorecognition in Botryllus schlosseri, a basal chordate which undergoes a natural transplantation reaction following contact between two individuals, and, analogous to vertebrates, is controlled by a single locus. We will summarize each of the known candidate genes within this locus and their potential roles in allorecognition, and speculate on how these findings may in fact be revealing potential functional relationships between disparate allorecognition systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.